ReviewImmunologic research2007
Neutrophils and TRAIL: insights into BCG immunotherapy for bladder cancer.
Review in Immunologic research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- A causal link between circulating leukocytes and three major urologic cancers: a mendelian randomization investigation.Frontiers in genetics · 2024Article
- Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity.Biomedicines · 2021Article
- Neutrophils: Many Ways to Die.Frontiers in immunology · 2021Review
- Article
- Certain BCG-reactive responses are associated with bladder cancer prognosis.Cancer immunology, immunotherapy : CII · 2018Article
- Article
- Immunological basis in the pathogenesis and treatment of bladder cancer.Expert review of clinical immunology · 2015Review
- Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study.BJU international · 2015Article
- Immune therapies in non-muscle invasive bladder cancer.Current treatment options in oncology · 2015Review
- Replication-competent adenovirus expressing TRAIL synergistically potentiates the antitumor effect of gemcitabine in bladder cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-α but not through TRAIL and FasL.Journal of leukocyte biology · 2012Article
- HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer.PloS one · 2012Article
- Antitumor Efficacy of Intravesical BCG, Gemcitabine, Interferon-α and Interleukin-2 as Mono- or Combination-Therapy for Bladder Cancer in an Orthotopic Tumor Model.Clinical Medicine Insights. Oncology · 2011Article
- Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer.Cancer metastasis reviews · 2009Review
- Bacillus Calmette-Guerin immunotherapy for urothelial carcinoma of the bladder.Immunotherapy · 2009Review
- Immunology at the University of Iowa.Immunologic research · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Bladder cancer is a huge economic burden on the healthcare system and is responsible for approximately 5% of all cancer deaths in humans. Mycobacterium bovis BCG-based therapy is the treatment of choice for superficial bladder cancer. Bacillus Calmette-Guerin (BCG) instillation in the bladder results in a massive local inflammatory response that has secondary antitumor properties. Recent studies have demonstrated that neutrophils present in the bladder after BCG instillation release large amounts of the apoptosis-inducing molecule TRAIL, as well as chemokines that recruit other immune cells, suggesting that neutrophils play a key role in the antitumor response to BCG therapy. This review discusses the impact of these findings on the understanding of the antitumor mechanisms underlying BCG-based immunotherapy for bladder cancer.
Indexed as
Identifiers
17917057What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.