ReviewImmunologic research2007
The isolator piglet: a model for studying the development of adaptive immunity.
Review in Immunologic research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Environmental and developmental factors shape anti-AAV immunity in pigs.Gene therapy · 2026Article
- Impact of Early Weaning on Development of the Swine Gut Microbiome.Microorganisms · 2023Review
- Testable Candidate Immune Correlates of Protection for Porcine Reproductive and Respiratory Syndrome Virus Vaccination.Vaccines · 2023Review
- Interleukin-17 producing cells in swine induced by microbiota during the early postnatal period - a brief research report.Frontiers in immunology · 2023Article
- Modified live vaccine strains of porcine reproductive and respiratory syndrome virus cause immune system dysregulation similar to wild strains.Frontiers in immunology · 2023Article
- Article
- Immunocyte Populations Observed from Birth to Weaning in Blood, Spleen and Mesenteric Lymph Nodes of Piglets.Animals : an open access journal from MDPI · 2022Article
- Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets.Mucosal immunology · 2021Article
- Temporal expression profiling of long noncoding RNA and mRNA in the peripheral blood during porcine development.Asian-Australasian journal of animal sciences · 2020Article
- The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut.Microbiology and molecular biology reviews : MMBR · 2019Review
- Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic.Immunologic research · 2014Review
- Article
- Paradigm of Time-sequence Development of the Intestine of Suckling Piglets with Microarray.Asian-Australasian journal of animal sciences · 2012Article
- The pig: a model for human infectious diseases.Trends in microbiology · 2012Review
- Safety of intra-articular use of atelocollagen for enhanced tissue repair.The open orthopaedics journal · 2012Article
- Distribution, organization and innervation of gastric MALT in conventional piglet.Journal of anatomy · 2011Article
- Generation of antibody- and B cell-deficient pigs by targeted disruption of the J-region gene segment of the heavy chain locus.Transgenic research · 2011Article
- Intestinal resection and anastomosis in neonatal gnotobiotic piglets.Journal of the American Association for Laboratory Animal Science : JAALAS · 2011Article
- Contribution of large pig for renal ischemia-reperfusion and transplantation studies: the preclinical model.Journal of biomedicine & biotechnology · 2011Review
- An activated immune and inflammatory response targets the pancreas of newborn pigs with cystic fibrosis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The period from late gestation to weaning in neonatal mammals is a critical window when the adaptive immune system develops and replaces the protection temporarily provided by passive immunity and pre-adaptive antibodies. It is also when oral tolerance to dietary antigen and the distinction between commensal and pathogenic gut bacteria becomes established resulting in immune homeostasis. The reproductive biology of swine provides a unique model for distinguishing the effects of different factors on immune development during this critical period because all extrinsic factors are controlled by the experimenter. This chapter reviews this early stage of development and the usefulness of the piglet model for understanding events during this transitional stage. The review also describes the major features of the porcine immune system and the immune stimulatory and dysregulatory factors that act during this period. The value of the model to medical science in such areas as food allergy, organ transplantation, cystic fibrosis and the production of humanized antibodies for immuno-therapy is discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.