ReviewImmunologic research2007
Th1 or Th2 balance regulated by interaction between dendritic cells and NKT cells.
Review in Immunologic research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Effects of Psychological Stress on Multiple SclerosisCNS & neurological disorders drug targets · 2024Review
- Transcriptomic analysis reveal the responses of dendritic cells to VDBP.Genes & genomics · 2022Article
- Calcium Signaling in T Cells and Chronic Inflammatory Disorders of the Oral Cavity.Journal of dental research · 2021Review
- TLR4 antagonist suppresses airway remodeling in asthma by inhibiting the T-helper 2 response.Experimental and therapeutic medicine · 2017Article
- Effect of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol on Immune Functions in Healthy Adults in a Randomized Controlled Trial.Immune network · 2015Article
- Omalizumab for difficult-to-treat dermatological conditions: clinical and immunological features from a retrospective real-life experience.Clinical drug investigation · 2015Article
- Dental Pulp Defence and Repair Mechanisms in Dental Caries.Mediators of inflammation · 2015Review
- Suppression of Th1 cytokine production by a peptide derived from C4b.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Pretreatment levels of circulating Th1 and Th2 cytokines, and their ratios, are associated with ER-negative and triple negative breast cancers.Breast cancer research and treatment · 2013Article
- The mechanism of the anticancer function of M1 macrophages and their use in the clinic.Chinese journal of cancer · 2012Review
- CD4+ T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4+ T cells to direct T helper 2 cell differentiation.The Journal of biological chemistry · 2012Article
- Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides.Journal of medicinal chemistry · 2011Article
- Alloantigen specific deletion of primary human T cells by Fas ligand (CD95L)-transduced monocyte-derived killer-dendritic cells.Immunology · 2011Article
- Primary human mDC1, mDC2, and pDC dendritic cells are differentially infected and activated by respiratory syncytial virus.PloS one · 2011Article
- Intermittent hypoxia mobilizes hematopoietic progenitors and augments cellular and humoral elements of innate immunity in adult men.High altitude medicine & biology · 2011Article
- Type I natural killer T cells: naturally born for fighting.Acta pharmacologica Sinica · 2010Review
- Alpha versus beta: are we on the way to resolve the mystery as to which is the endogenous ligand for natural killer T cells?Clinical and experimental immunology · 2009Article
- Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease.Frontiers in neuroendocrinology · 2009Review
- Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
If Th1 or Th2 polarization could be artificially manipulated, effective immune responses would be generated depending on nature of the targets. In this study we attempted to regulate CD40 expressions on dendritic cells (DCs) in order to modify the T cell response. It was found that reducing agents selectively inhibited surface expression of CD40 on DCs. This finding may provide a new strategy of DC-mediated modulation of the Th1/Th2 balance. It was also shown that NKT-produced Th1/Th2 cytokine balance was under control of negative feedback loop through DCs. Th1 cytokine-pretreated DCs mainly induced Th2 cytokine production, whereas Th2 cytokine-pretreated DCs induced Th1 cytokine production by alpha-galactosylceramide-stimulated NKT cells. The negative feedback regulation system could be applicable to therapeutics of various diseases based on immunological disorders.
Indexed as
Identifiers
17917039What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.