ArticleThe Journal of physiology2007
Kinetics of both synchronous and asynchronous quantal release during trains of action potential-evoked EPSCs at the rat calyx of Held.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses.eLife · 2023Article
- Complexins: Ubiquitously Expressed Presynaptic Regulators of SNARE-Mediated Synaptic Vesicle Fusion.Advances in neurobiology · 2023Article
- A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Short-term synaptic depression can increase the rate of information transfer at a release site.PLoS computational biology · 2019Article
- The calyx of Held in the auditory system: Structure, function, and development.Hearing research · 2016Review
- Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Different types of retinal inhibition have distinct neurotransmitter release properties.Journal of neurophysiology · 2015Article
- Ca2+ channel to synaptic vesicle distance accounts for the readily releasable pool kinetics at a functionally mature auditory synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Vesicles derived via AP-3-dependent recycling contribute to asynchronous release and influence information transfer.Nature communications · 2014Article
- Biophysical properties of presynaptic short-term plasticity in hippocampal neurons: insights from electrophysiology, imaging and mechanistic models.Frontiers in cellular neuroscience · 2014Review
- Estimation of the time course of neurotransmitter release at central synapses from the first latency of postsynaptic currents.Journal of neuroscience methods · 2012Article
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- Modelling vesicular release at hippocampal synapses.PLoS computational biology · 2010Article
- Desynchronization of neocortical networks by asynchronous release of GABA at autaptic and synaptic contacts from fast-spiking interneurons.PLoS biology · 2010Article
- Bidirectional neuron-glia interactions triggered by deficiency of glutamate uptake at spinal sensory synapses.Journal of neurophysiology · 2010Article
- A comparison of deterministic and stochastic simulations of neuronal vesicle release models.Physical biology · 2010Article
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- Article
- Fluctuation analysis of tetanic rundown (short-term depression) at a corticothalamic synapse.Biophysical journal · 2009Article
- Synaptic vesicles in mature calyx of Held synapses sense higher nanodomain calcium concentrations during action potential-evoked glutamate release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the kinetics of transmitter release during trains of action potential (AP)-evoked excitatory postsynaptic currents (EPSCs) at the calyx of Held synapse of juvenile rats. Using a new quantitative method based on a combination of ensemble fluctuation analysis and deconvolution, we were able to analyse mean quantal size (q) and release rate (xi) continuously in a time-resolved manner. Estimates derived this way agreed well with values of q and quantal content (M) calculated for each EPSC within the train from ensemble means of peak amplitudes and their variances. Separate analysis of synchronous and asynchronous quantal release during long stimulus trains (200 ms, 100 Hz) revealed that the latter component was highly variable among different synapses but it was unequivocally identified in 18 out of 37 synapses analysed. Peak rates of asynchronous release ranged from 0.2 to 15.2 vesicles ms(-1) (ves ms(-1)) with a mean of 2.3 +/- 0.6 ves ms(-1). On average, asynchronous release accounted for less than 14% of the total number of about 3670 +/- 350 vesicles released during 200 ms trains. Following such trains, asynchronous release decayed with several time constants, the fastest one being in the order of 15 ms. The short duration of asynchronous release at the calyx of Held synapse may aid in generating brief postsynaptic depolarizations, avoiding temporal summation and preserving action potential timing during high frequency bursts.
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