ArticleThe Journal of physiology2007
Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 78 citations in OpenAlex.
- Synaptic Vesicle Recycling at the Developing Presynapse.Journal of neurochemistry · 2025Review
- Maturation of glutamatergic transmission onto dorsal raphe serotonergic neurons.Journal of neurophysiology · 2024Article
- Postnatal development of electrophysiological and morphological properties in layer 2/3 and layer 5 pyramidal neurons in the mouse primary visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain.Frontiers in synaptic neuroscience · 2023Review
- Developmental depression-to-facilitation shift controls excitation-inhibition balance.Communications biology · 2022Article
- Energetics of stochastic BCM type synaptic plasticity and storing of accurate information.Journal of computational neuroscience · 2021Article
- Adenosine Receptor-Mediated Developmental Loss of Spike Timing-Dependent Depression in the Hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- NMDA Receptors Containing GluN2B/2C/2D Subunits Mediate an Increase in Glutamate Release at Hippocampal CA3-CA1 Synapses.Molecular neurobiology · 2019Article
- Developmental Increase of Neocortical Presynaptic EfficacyFrontiers in synaptic neuroscience · 2019Article
- Diffusion of CaBiophysical journal · 2018Article
- Developmental Changes in Serotonergic Modulation of GABAergic Synaptic Transmission and Postsynaptic GABACerebellum (London, England) · 2018Article
- Transmission of temporally correlated spike trains through synapses with short-term depression.PLoS computational biology · 2018Article
- A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells.Molecular psychiatry · 2018Article
- Criteria on Balance, Stability, and Excitability in Cortical Networks for Constraining Computational Models.Frontiers in computational neuroscience · 2018Article
- Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex.Frontiers in synaptic neuroscience · 2018Article
- Numbers of presynaptic CaProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Synaptic scaling rule preserves excitatory-inhibitory balance and salient neuronal network dynamics.Nature neuroscience · 2016Article
- Development of Synaptic Boutons in Layer 4 of the Barrel Field of the Rat Somatosensory Cortex: A Quantitative Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The probability of synaptic transmitter release determines the spread of excitation and the possible range of computations at unitary connections. To investigate whether synaptic properties between neocortical pyramidal neurons change during the assembly period of cortical circuits, whole-cell voltage recordings were made simultaneously from two layer 5A (L5A) pyramidal neurons within the cortical columns of rat barrel cortex. We found that synaptic transmission between L5A pyramidal neurons is very reliable between 2 and 3 weeks of postnatal development with a mean unitary EPSP amplitude of approximately 1.2 mV, but becomes less efficient and fails more frequently in the more mature cortex of approximately 4 weeks of age with a mean unitary EPSP amplitude of 0.65 mV. Coefficient of variation and failure rate increase as the unitary EPSP amplitude decreases during development. The paired-pulse ratio (PPR) of synaptic efficacy at 10 Hz changes from 0.7 to 1.04. Despite the overall increase in PPR, short-term plasticity displays a large variability at 4 weeks, ranging from strong depression to strong facilitation (PPR, range 0.6-2.1), suggesting the potential for use-dependent modifications at this intracortical synapse. In conclusion, the transmitter release probability at the L5A-L5A connection is developmentally regulated in such a way that in juvenile animals excitation by single action potentials is efficiently transmitted, whereas in the more mature cortex synapses might be endowed with a diversity of filtering characteristics.
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