ArticleBrain research2007
Activation of the serotonin 1A receptor alters the temporal characteristics of auditory responses in the inferior colliculus.
Article in Brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain.The Journal of comparative neurology · 2026Article
- Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome.Journal of neurodevelopmental disorders · 2025Article
- Altered brain serotonin 5-HTNeuropharmacology · 2024Article
- Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice.Frontiers in human neuroscience · 2023Article
- 5-HT1A Receptors Alter Temporal Responses to Broadband Vocalizations in the Mouse Inferior Colliculus Through Response Suppression.Frontiers in neural circuits · 2021Article
- Silence, Solitude, and Serotonin: Neural Mechanisms Linking Hearing Loss and Social Isolation.Brain sciences · 2020Review
- Examining the underpinnings of loudness dependence of auditory evoked potentials with positron emission tomography.NeuroImage · 2020Article
- Putting it in Context: Linking Auditory Processing with Social Behavior Circuits in the Vertebrate Brain.Integrative and comparative biology · 2017Review
- Serotonin modulates response properties of neurons in the dorsal cochlear nucleus of the mouse.Hearing research · 2017Article
- Serotonin, estrus, and social context influence c-Fos immunoreactivity in the inferior colliculus.Behavioral neuroscience · 2016Article
- Socially induced serotonergic fluctuations in the male auditory midbrain correlate with female behavior during courtship.Journal of neurophysiology · 2016Article
- Acoustic trauma triggers upregulation of serotonin receptor genes.Hearing research · 2014Article
- Sound-by-sound thalamic stimulation modulates midbrain auditory excitability and relative binaural sensitivity in frogs.Frontiers in neural circuits · 2014Article
- Duration tuning across vertebrates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- From behavioral context to receptors: serotonergic modulatory pathways in the IC.Frontiers in neural circuits · 2012Article
- Plasticity of serotonergic innervation of the inferior colliculus in mice following acoustic trauma.Hearing research · 2012Article
- Context-dependent modulation of auditory processing by serotonin.Hearing research · 2011Review
- Social regulation of serotonin in the auditory midbrain.Behavioral neuroscience · 2011Article
- 5-HT1A and 5-HT1B receptors differentially modulate rate and timing of auditory responses in the mouse inferior colliculus.The European journal of neuroscience · 2010Article
- Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus.Hearing research · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Serotonin, like other neuromodulators, acts on a range of receptor types, but its effects also depend on the functional characteristics of the neurons responding to receptor activation. In the inferior colliculus (IC), an auditory midbrain nucleus, activation of a common serotonin (5-HT) receptor type, the 5-HT 1A receptor, depresses auditory-evoked responses in many neurons. Whether these effects occur differentially in different types of neurons is unknown. In the current study, the effects of iontophoretic application of the 5-HT 1A agonist 8-OH-DPAT on auditory responses were compared with the characteristic frequencies (CFs), recording depths, and control first-spike latencies of the same group of IC neurons. The 8-OH-DPAT-evoked change in response significantly correlated with first-spike latency across the population, so that response depressions were more prevalent in longer-latency neurons. The 8-OH-DPAT-evoked change in response did not correlate with CF or with recording depth. 8-OH-DPAT also altered the temporal characteristics of spike trains in a subset of neurons that fired multiple spikes in response to brief stimuli. For these neurons, activation of the 5-HT 1A receptor suppressed lagging spikes proportionally more than initial spikes. These results suggest that the 5-HT 1A receptor, by affecting the timing of the responses of both individual neurons and the neuron population, shifts the temporal profile of evoked activity within the IC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.