ArticleLife sciences2007
Nitric oxide signaling participates in norepinephrine-induced activity of neuronal intracellular survival pathways.
Article in Life sciences, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Noradrenergic Projections from the Locus Coeruleus to the Medial Prefrontal Cortex Enhances Stress Coping Behavior in Mice Following Long-Term Intermittent Fasting.Neuromolecular medicine · 2024Article
- Neuroprotective actions of norepinephrine in neurological diseases.Pflugers Archiv : European journal of physiology · 2024Review
- Associations between MRI-assessed locus coeruleus integrity and cortical gray matter microstructure.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms.Scientific reports · 2022Article
- Noradrenergic Modulation on Dopaminergic Neurons.Neurotoxicity research · 2018Review
- Significant Acute Response of Brain-Derived Neurotrophic Factor Following a Session of Extreme Conditioning Program Is Correlated With Volume of Specific Exercise Training in Trained Men.Frontiers in physiology · 2018Article
- Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1.Frontiers in neuroscience · 2015Article
- Physical activity, air pollution and the brain.Sports medicine (Auckland, N.Z.) · 2014Review
- Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF.Pharmacology, biochemistry, and behavior · 2011Article
- Physical activity and telomere biology: exploring the link with aging-related disease prevention.Journal of aging research · 2011Article
- Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Running exercise-induced up-regulation of hippocampal brain-derived neurotrophic factor is CREB-dependent.Hippocampus · 2009Article
- AKT/eNOS signaling module functions as a potential feedback loop in the growth hormone signaling pathway.Journal of molecular signaling · 2009Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Much evidence has gathered that nitric oxide (NO) signaling, via cGMP-dependent mechanisms, may activate pro-survival pathways in hippocampal neurons and inhibit apoptosis. Past research has revealed that the enhancement of monoaminergic neurotransmission via exercise or treatment with antidepressant medications leads to an enhanced expression of brain-derived neurotrophic factor (BDNF). In isolated hippocampal neurons, norepinephrine (NE) application also increases the immunoreactivity of BDNF and several pro-survival signaling molecules. The data herein support the possibility that NO signaling plays an important role in enhancing neurotrophin expression and activation of the pro-survival phosphatidylinositol 3' kinase (PI-3K) pathway stimulated by NE. In isolated hippocampal neurons, the NO donor, sodium nitroprusside, increases BDNF, PI-3K, and phospho-ERK1 immunoreactivity. Specific inhibitors of the NO system suggest that NE-induced increases in hippocampal BDNF and the PI-3K pathway, but not stimulation of the MAPK pathway, depend upon NO signaling. In addition, inhibiting cGMP suggest that the effects of NE on BDNF immunoreactivity and Akt phosphorylation are also cGMP-dependent. Finally, the application of l-NAME to hippocampal neurons increases cell death. This is the first study of its kind demonstrating the involvement of NE-induced pro-survival signaling in three distinct signaling pathways: PI-3K, MAPK, and NO/cGMP. Possible mechanisms are discussed in light of the results.
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Registered trials
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