Evidence map›Paper›PMID 17915073›Full record

ReviewCurrent psychiatry reports2007

Genetics and smoking behavior.

Robert A Schnoll, Terrance A Johnson, Caryn Lerman

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Current psychiatry reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01186016 nacompletednot on this mapstarted 2010, after this paper: background citation

Developing Genetic Education for Smoking Cessation

TypeinterventionalSponsorUniversity of NebraskaRan2010 to 2012Enrolled103ConditionsTobacco SmokingArmsGenetic Education Session, Nutrition Education Session
NCT07104006 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Development and Testing of a Smoking Cessation Intervention Using Multi-Theory Model (MTM) Among Young Adults: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of Nevada, Las VegasRan2025 to 2026Enrolled144ConditionsTobacco Use Disorder/Cigarette SmokingArmsMulti-Theory Model (MTM)-Based Smoking Cessation Program
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Genotype × Environment Interaction in Smoking Behaviors: A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Hypomethylation ofGenes · 2021
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. A survey on computer aided diagnosis for ocular diseases.BMC medical informatics and decision making · 2014
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert A SchnollDepartment of Psychiatry, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA. schnoll@mail.med.upenn.edu
Terrance A Johnson
Caryn Lerman

Funding

TRANSDISCIPLINARY TOBACCO USE RESEARCH CENTERSP50CA084718 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LERMAN, CARYN · 1999 to 2008
$17.8M
Smoking Cessation for Head and Neck Cancer PatientsR01CA095678 · NCI · UNIVERSITY OF PENNSYLVANIA · PI SCHNOLL, ROBERT A · 2002 to 2006
$2.8M
NCI NIH HHS P50 DA/CA 84718NCI NIH HHS R01 CA 95678
6 · The paper itself

Abstract

Accumulating data support the role of genetic factors in smoking initiation, progression to tobacco dependence, and smoking persistence. This review summarizes current research on the heritability of tobacco use phenotypes and genetic association studies of smoking-related behaviors. Although progress has been made in genetics research on smoking behavior, many studies have methodological limitations, including insufficient samples for detecting gene-gene and gene-environment interactions and use of less refined phenotypes. Pharmacogenetic investigations also are identifying variants in drug-metabolizing enzymes, receptors, and transporters that modify therapeutic response to smoking cessation medications; however, the field is relatively new, and most findings in this area have yet to be replicated. As this research advances, it will be important to study and address practical, economic, ethical, and social barriers to the translation of genetics research on tobacco use to clinical practice.

Indexed as

AllelesAryl Hydrocarbon HydroxylasesCytochrome P-450 CYP2A6Genetic Predisposition to DiseaseGenetic ResearchHumansMixed Function OxygenasesNicotinePharmacogeneticsPhenotypeSmokingSmoking CessationTobacco Use DisorderTreatment OutcomeAryl Hydrocarbon HydroxylasesCytochrome P-450 CYP2A6Mixed Function OxygenasesNicotine

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.