ArticlePLoS biology2007
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 1 of them a synthesis that pooled it.
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Who cites it
182 citing papers in PubMed, 1 synthesis or guideline pooled it, 313 citations in OpenAlex.
- Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2014Pooled it
- Established determinants of replicative lifespan, including mitochondrial DNA, play a limited role in early yeast stress-resistance decline.Biogerontology · 2026Article
- Molecular Targets in Modern Cosmetic Science.Molecules (Basel, Switzerland) · 2026Review
- Bench to bedside: is rapamycin headed for the docTOR?GeroScience · 2026Review
- Regulation of survival, growth, and metabolism by neuronal mTOR.GeroScience · 2026Article
- Single-cell analyses identify independent aging processes that compete to determine cellular fate in budding yeast.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans.Journal of biomedical science · 2025Review
- Design principles of gene circuits for longevity.Trends in cell biology · 2025Review
- NADCells · 2025Review
- Calorie restriction mimetics against aging and inflammation.Biogerontology · 2025Review
- Enhanced cellular longevity arising from environmental fluctuations.Cell systems · 2024Article
- An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo.Genome medicine · 2024Article
- Chromatin regulator Eaf3p regulates nitrogen metabolism inApplied and environmental microbiology · 2023Article
- Article
- Dietary change without caloric restriction maintains a youthful profile in ageing yeast.PLoS biology · 2023Article
- Targeting the biology of aging with mTOR inhibitors.Nature aging · 2023Review
- Rapamycin Responds to Alzheimer's Disease: A Potential Translational Therapy.Clinical interventions in aging · 2023Review
- Gentirigeoside B fromAntioxidants (Basel, Switzerland) · 2022Article
- Molecular inhibition of RAS signalling to target ageing and age-related health.Disease models & mechanisms · 2022Review
- A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.Science advances · 2022Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Calorie restriction (CR) robustly extends the lifespan of numerous species. In the yeast Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the activity of sirtuin deacetylases, thereby suppressing the formation of toxic repetitive ribosomal DNA (rDNA) circles. An alternative theory is that CR works by suppressing the TOR (target of rapamycin) signaling pathway, which extends lifespan via mechanisms that are unknown but thought to be independent of sirtuins. Here we show that TOR inhibition extends lifespan by the same mechanism as CR: by increasing Sir2p activity and stabilizing the rDNA locus. Further, we show that rDNA stabilization and lifespan extension by both CR and TOR signaling is due to the relocalization of the transcription factors Msn2p and Msn4p from the cytoplasm to the nucleus, where they increase expression of the nicotinamidase gene PNC1. These findings suggest that TOR and sirtuins may be part of the same longevity pathway in higher organisms, and that they may promote genomic stability during aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.