ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Hippocampal alpha4beta2 nicotinic acetylcholine receptor involvement in the enhancing effect of acute nicotine on contextual fear conditioning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 107 citations in OpenAlex.
- Nicotine reduces discrimination between threat and safety in the hippocampus, nucleus accumbens and amygdala.Translational psychiatry · 2024Trial
- Nicotine effects on associative learning in human non-smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Varenicline improves mood and cognition during smoking abstinence.Biological psychiatry · 2009Trial
- Increased Binding of [Synapse (New York, N.Y.) · 2026Article
- Hypertension Induces Cognitive Impairment and Alterations of Acetylcholine Receptor mRNA Expression in the Hippocampus and Cortex of Mice.Neuromolecular medicine · 2025Article
- Reduction in [Brain research · 2025Article
- Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment.Biology of sex differences · 2024Article
- Basal forebrain cholinergic systems as circuits through which traumatic stress disrupts emotional memory regulation.Neuroscience and biobehavioral reviews · 2024Review
- Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood.Pharmacology, biochemistry, and behavior · 2022Review
- Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function.Neuropharmacology · 2018Article
- Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus.Journal of psychopharmacology (Oxford, England) · 2017Article
- α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation.Neuropharmacology · 2016Article
- The role of basal forebrain cholinergic neurons in fear and extinction memory.Neurobiology of learning and memory · 2016Review
- Adolescent mice are less sensitive to the effects of acute nicotine on context pre-exposure than adults.Brain research · 2016Article
- Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory.Physiology & behavior · 2016Review
- High-affinity α4β2 nicotinic receptors mediate the impairing effects of acute nicotine on contextual fear extinction.Neurobiology of learning and memory · 2016Article
- Acute administration of nicotine into the higher order auditory Te2 cortex specifically decreases the fear-related charge of remote emotional memories.Neuropharmacology · 2015Article
- Negative affective states and cognitive impairments in nicotine dependence.Neuroscience and biobehavioral reviews · 2015Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nicotine is known to enhance learning and memory in hippocampus-dependent tasks such as contextual fear conditioning. The present study was designed to directly examine whether the hippocampus plays a role in mediating this enhancement and which nicotinic acetylcholine receptor (nAChR) subtypes localized to the hippocampus are critical for enhanced learning. Contextual fear conditioning consisted of two white noise conditioned stimuli presentations, each coterminating with a 2 s, 0.57 mA footshock separated by a 120 s intertrial interval. Nicotine (0.09, 0.18, and 0.35 microg per side) was bilaterally infused into the dorsal hippocampus before training and testing. Infusions of nicotine into the dorsal hippocampus produced a dose-dependent enhancement of contextual fear conditioning. To determine which nAChRs are critical to the enhancing effect of nicotine, the preferential alpha4beta2 nAChR antagonist, dihydro-beta-erythroidine (DHbetaE) (6.00 and 18.00 microg per side), or the preferential alpha7 nAChR antagonist, methyllycaconitine (MLA) (13.50 and 27.00 microg per side), was bilaterally infused into the dorsal hippocampus before systemic injections of nicotine (0.09 mg/kg). DHbetaE infusions dose-dependently blocked the enhancement of contextual fear conditioning by nicotine, whereas MLA infusions yielded an intermediate effect. In addition, neither DHbetaE nor MLA had an effect on contextual fear conditioning in the absence of systemic nicotine. The present results suggest a critical role for alpha4beta2 nAChRs in the dorsal hippocampus for mediating the enhancing effect of nicotine on contextual fear conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.