ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
State dependence of spike timing and neuronal function in a motor pattern generating network.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A brain-gut excitatory peptide/CCHamide homolog regulates satiation and motivational state transitions in the Aplysia feeding circuit.The Journal of biological chemistry · 2026Article
- Synaptic and intrinsic plasticity mediated by CCK-type signaling coordinates behavioral changes during motivational state shifts.Cell reports · 2025Article
- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Newly Identified Aplysia SPTR-Gene Family-Derived Peptides: Localization and Function.ACS chemical neuroscience · 2018Article
- Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model,The Journal of biological chemistry · 2017Article
- Functional Characterization of a Vesicular Glutamate Transporter in an Interneuron That Makes Excitatory and Inhibitory Synaptic Connections in a Molluscan Neural Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Specificity of repetition priming: the role of chemical coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Complementary interactions between command-like interneurons that function to activate and specify motor programs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effect of presynaptic membrane potential on electrical vs. chemical synaptic transmission.Journal of neurophysiology · 2011Article
- Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational difference analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Repetition priming of motoneuronal activity in a small motor network: intercellular and intracellular signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Composite modulatory feedforward loop contributes to the establishment of a network state.Journal of neurophysiology · 2010Article
- Distinct mechanisms produce functionally complementary actions of neuropeptides that are structurally related but derived from different precursors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Motor outputs in a multitasking network: relative contributions of inputs and experience-dependent network states.Journal of neurophysiology · 2009Article
- Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Neural analog of arousal: persistent conditional activation of a feeding modulator by serotonergic initiators of locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- An input-representing interneuron regulates spike timing and thereby phase switching in a motor network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Predicting adaptive behavior in the environment from central nervous system dynamics.PloS one · 2008Article
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Authors and funding
6 authors.
Funding
Abstract
When sustained firing of a neuron is similar in different types of motor programs, its role in the generation of these programs is often similar. We investigated whether this is also the case for neurons involved in phase transition. In the Aplysia feeding central pattern generator (CPG), identified interneuron B64 starts firing at the transition between the protraction and the retraction phases of all types of motor programs, and its firing is sustained during the retraction phase. It was thought that B64 functions as a protraction terminator as it provides strong inhibitory input to protraction interneurons and motoneurons. Furthermore, premature activation of B64 can lead to premature termination of the protraction phase. Indeed, as we show here, B64 can terminate the protraction phase regardless of the type of motor program. However, B64 actually only functions as a protraction terminator in ingestive-like but not in egestive-like programs. This differential role of B64 results from a differential timing of the initiation of B64 spiking in the two types of programs. In turn, this differential timing of the initiation of B64 firing is determined by the internal state of the CPG. Thus, this study indicates the importance of the timing of initiation of firing in determining the functional role of a neuron and demonstrates that this role depends on the activity-dependent state of the network.
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