ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Navigating neocortical neurogenesis and neuronal specification: a positional information system encoded by neurogenetic gradients.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Differential neurogenic patterns underlie the formation of primary and secondary areas in the developing somatosensory cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Cytomegalovirus infection lengthens the cell cycle of granule cell precursors during postnatal cerebellar development.JCI insight · 2024Article
- Microglial Characterization in Transient Human Neurodevelopmental Structures.Developmental neuroscience · 2023Article
- How mechanisms of stem cell polarity shape the human cerebral cortex.Nature reviews. Neuroscience · 2022Review
- Systematic modelling of the development of laminar projection origins in the cerebral cortex: Interactions of spatio-temporal patterns of neurogenesis and cellular heterogeneity.PLoS computational biology · 2020Article
- Distinct timing of neurogenesis of ipsilateral and contralateral retinal ganglion cells.The Journal of comparative neurology · 2019Article
- Comprehensive computational modelling of the development of mammalian cortical connectivity underlying an architectonic type principle.PLoS computational biology · 2018Article
- Cross-Regional Gradient of Dendritic Morphology in Isochronically-Sourced Mouse Supragranular Pyramidal Neurons.Frontiers in neuroanatomy · 2018Article
- Neural Stem Cells to Cerebral Cortex: Emerging Mechanisms Regulating Progenitor Behavior and Productivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Evolution of cytoarchitectural landscapes in the mammalian isocortex: Sirenians (Trichechus manatus) in comparison with other mammals.The Journal of comparative neurology · 2016Article
- Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Systematic, cross-cortex variation in neuron numbers in rodents and primates.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Finding degrees of separation: experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting.Journal of neuroscience methods · 2014Review
- Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice.Neural development · 2014Article
- Evo-devo and the primate isocortex: the central organizing role of intrinsic gradients of neurogenesis.Brain, behavior and evolution · 2014Article
- Ex utero electroporation and whole hemisphere explants: a simple experimental method for studies of early cortical development.Journal of visualized experiments : JoVE · 2013Article
- p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortex.Development (Cambridge, England) · 2012Article
- A lifespan analysis of intraneocortical connections and gene expression in the mouse II.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
- Neocortical neurogenesis: morphogenetic gradients and beyond.Trends in neurosciences · 2009Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The projection neurons of the neocortex are produced in the pseudostratified ventricular epithelium (PVE) lining the embryonic lateral ventricles. Over a 7 d period in mouse, these neurons arise in an overlapping layer VI-to-II sequence and in an anterolateral to posteromedial gradient [the transverse neurogenetic gradient (TNG)]. At any time in the 7 d neurogenetic interval, a given PVE cell must know what class of precursor cell or neuron to form next. How this information is encoded in the PVE is not known. With comparative experiments in wild-type and double-transgenic mice, overexpressing the cell cycle inhibitor p27(Kip1), we show that a gradient of expression of Lhx2 (inferred from its mRNA levels), a LIM homeodomain transcription factor, together with a gradient in duration of the G1 phase of the cell cycle (T(G1)), are sufficient to specify a positional mapping system that informs the PVE cell what class of neuron to produce next. Lhx2 likely is representative of an entire class of transcription factors expressed along the TNG. This mapping system consisting of a combination of signals from two different sources is a novel perspective on the source of positional information for neuronal specification in the developing CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.