ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Neural correlates of tactile detection: a combined magnetoencephalography and biophysically based computational modeling study.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04062318 (The Causal Role of Neocortical Beta Events in Human Sensory Perception), which is not on this map. Cited by 85 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Causal Role of Neocortical Beta Events in Human Sensory Perception
Who cites it
85 citing papers in PubMed.
- Cutaneous Sensory Stimulation Intensity Modulates Beta-Band Event-Related Desynchronization and Synchronization Amplitudes.The European journal of neuroscience · 2026Article
- Deviance detection via competitive inhibition between local neocortical ensembles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Conscious Tactile Perception Depends on Early Processing in Primary Somatosensory Cortex.The European journal of neuroscience · 2026Article
- Uncovering putative neural mechanisms of neurotherapeutic impacts on EEG using the Human Neocortical Neurosolver.bioRxiv : the preprint server for biology · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Computational modeling reveals biological mechanisms underlying the whisker flick EEG.iScience · 2025Article
- Neurophysiology of mismatch negativity generation: a biophysical modeling study.bioRxiv : the preprint server for biology · 2025Article
- Deviance detection via competitive inhibition between local neocortical ensembles.bioRxiv : the preprint server for biology · 2025Article
- Biophysical Modeling of Frontocentral ERP Generation Links Circuit-Level Mechanisms of Action-Stopping to a Behavioral Race Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuronal Modeling of Cross-Sensory Visual Evoked Magnetoencephalography Responses in the Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Isolating Neural Signatures of Conscious Speech Perception with a No-Report Sine-Wave Speech Paradigm.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuronal modeling of magnetoencephalography responses in auditory cortex to auditory and visual stimuli.bioRxiv : the preprint server for biology · 2024Article
- Methods and considerations for estimating parameters in biophysically detailed neural models with simulation based inference.PLoS computational biology · 2024Article
- The auditory P2 is influenced by pitch changes but not pitch strength and consists of two separate subcomponents.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Distinct neocortical mechanisms underlie human SI responses to median nerve and laser-evoked peripheral activation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Agranular frontal cortical microcircuit underlying cognitive control in macaques.Frontiers in neural circuits · 2024Review
- Stimulus awareness is associated with secondary somatosensory cortex activation in an inattentional numbness paradigm.Scientific reports · 2023Article
- Cortical origin of theta error signals.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Biophysical modeling of frontocentral ERP generation links circuit-level mechanisms of action-stopping to a behavioral race model.bioRxiv : the preprint server for biology · 2023Article
- Laminar specificity of the auditory perceptual awareness negativity: A biophysical modeling study.PLoS computational biology · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Previous reports conflict as to the role of primary somatosensory neocortex (SI) in tactile detection. We addressed this question in normal human subjects using whole-head magnetoencephalography (MEG) recording. We found that the evoked signal (0-175 ms) showed a prominent equivalent current dipole that localized to the anterior bank of the postcentral gyrus, area 3b of SI. The magnitude and timing of peaks in the SI waveform were stimulus amplitude dependent and predicted perception beginning at approximately 70 ms after stimulus. To make a direct and principled connection between the SI waveform and underlying neural dynamics, we developed a biophysically realistic computational SI model that contained excitatory and inhibitory neurons in supragranular and infragranular layers. The SI evoked response was successfully reproduced from the intracellular currents in pyramidal neurons driven by a sequence of lamina-specific excitatory input, consisting of output from the granular layer (approximately 25 ms), exogenous input to the supragranular layers (approximately 70 ms), and a second wave of granular output (approximately 135 ms). The model also predicted that SI correlates of perception reflect stronger and shorter-latency supragranular and late granular drive during perceived trials. These findings strongly support the view that signatures of tactile detection are present in human SI and are mediated by local neural dynamics induced by lamina-specific synaptic drive. Furthermore, our model provides a biophysically realistic solution to the MEG signal and can predict the electrophysiological correlates of human perception.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.