ArticleJournal of virology2008
TRAIL is a novel antiviral protein against dengue virus.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Consensus transcriptional signature of dengue virus infection reveals coordinated interferon suppression and stress-response activation.Cell biochemistry and biophysics · 2026Article
- Review
- Inhibition of MAVS Aggregation-Mediated Type-I Interferon Signaling by Foot-and-Mouth Disease Virus VP3.Viruses · 2021Article
- Crocetin Improves Dengue Virus-Induced Liver Injury.Viruses · 2020Article
- Multivariate time-series analysis of biomarkers from a dengue cohort offers new approaches for diagnosis and prognosis.PLoS neglected tropical diseases · 2020Article
- Defining the role of NK cells during dengue virus infection.Immunology · 2018Review
- Principal Components Analysis Based Unsupervised Feature Extraction Applied to Gene Expression Analysis of Blood from Dengue Haemorrhagic Fever Patients.Scientific reports · 2017Article
- Article
- Dengue Virus Induces NK Cell Activation through TRAIL Expression during Infection.Mediators of inflammation · 2017Article
- Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection.International journal of molecular sciences · 2016Article
- Viability and Functionality of Cryopreserved Peripheral Blood Mononuclear Cells in Pediatric Dengue.Clinical and vaccine immunology : CVI · 2016Article
- Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease.Scientific reports · 2015Article
- IFI6 Inhibits Apoptosis via Mitochondrial-Dependent Pathway in Dengue Virus 2 Infected Vascular Endothelial Cells.PloS one · 2015Article
- Apoptotic mediators in patients with severe and non-severe dengue from Brazil.Journal of medical virology · 2014Article
- High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells.PloS one · 2014Article
- Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death.BMC research notes · 2013Article
- Article
- Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression.PloS one · 2013Article
- Dengue virus activates membrane TRAIL relocalization and IFN-α production by human plasmacytoid dendritic cells in vitro and in vivo.PLoS neglected tropical diseases · 2013Article
- Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Dengue fever is an important tropical illness for which there is currently no virus-specific treatment. To shed light on mechanisms involved in the cellular response to dengue virus (DV), we assessed gene expression changes, using Affymetrix GeneChips (HG-U133A), of infected primary human cells and identified changes common to all cells. The common response genes included a set of 23 genes significantly induced upon DV infection of human umbilical vein endothelial cells (HUVECs), dendritic cells (DCs), monocytes, and B cells (analysis of variance, P < 0.05). Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), one of the common response genes, was identified as a key link between type I and type II interferon response genes. We found that DV induces TRAIL expression in immune cells and HUVECs at the mRNA and protein levels. The induction of TRAIL expression by DV was found to be dependent on an intact type I interferon signaling pathway. A significant increase in DV RNA accumulation was observed in anti-TRAIL antibody-treated monocytes, B cells, and HUVECs, and, conversely, a decrease in DV RNA was seen in recombinant TRAIL-treated monocytes. Furthermore, recombinant TRAIL inhibited DV titers in DV-infected DCs by an apoptosis-independent mechanism. These data suggest that TRAIL plays an important role in the antiviral response to DV infection and is a candidate for antiviral interventions against DV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.