ArticleInternational journal of pharmaceutics2008
Permeability of surface-modified polyamidoamine (PAMAM) dendrimers across Caco-2 cell monolayers.
Article in International journal of pharmaceutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
- Multivalent Tranexamic Acid (TXA) and Benzamidine Derivatives for Serine Protease Inhibition.ACS pharmacology & translational science · 2025Article
- Dendrimer-Functionalized Hybrid Materials Based on Silica as Novel Carriers of Bioactive Acids.Molecules (Basel, Switzerland) · 2020Article
- Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH₂ Core and Evaluation of Their Anticancer Activity.Pharmaceutics · 2019Article
- Effect of 2nd and 3rd generation PAMAM dendrimers on proliferation, differentiation, and pro-inflammatory cytokines in human keratinocytes and fibroblasts.International journal of nanomedicine · 2019Article
- Pediatric oral formulation of dendrimer-N-acetyl-l-cysteine conjugates for the treatment of neuroinflammation.International journal of pharmaceutics · 2018Article
- Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells.Polymers · 2017Article
- In Vivo Nanodetoxication for Acute Uranium Exposure.Molecules (Basel, Switzerland) · 2015Article
- Dendrimer nanocarriers for transport modulation across models of the pulmonary epithelium.Molecular pharmaceutics · 2015Article
- Targeted delivery of polyamidoamine-paclitaxel conjugate functionalized with anti-human epidermal growth factor receptor 2 trastuzumab.International journal of nanomedicine · 2015Article
- Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors.Beilstein journal of nanotechnology · 2015Article
- In vitro cytotoxicity of the ternary PAMAM G3-pyridoxal-biotin bioconjugate.International journal of nanomedicine · 2013Article
- Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery.Advanced drug delivery reviews · 2012Review
- Dendritic Guanidines as Efficient Analogues of Cell Penetrating Peptides.Pharmaceuticals (Basel, Switzerland) · 2010Review
- Transepithelial transport of PEGylated anionic poly(amidoamine) dendrimers: implications for oral drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2009Article
- Poly(amido amine) dendrimers in oral delivery.Tissue barriersReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Aim of this study was to prepare polyamine-conjugated PAMAM dendrimers and study their permeability across Caco-2 cell monolayers. Polyamines, namely, arginine and ornithine were conjugated to the amine terminals of the G4 PAMAM dendrimers by Fmoc synthesis. The apical-to-basolateral (AB) and basolateral-to-apical (BA) apparent permeability coefficients (P(app)) for the PAMAM dendrimers increased by conjugating the dendrimers with both of the polyamines. The enhancement in permeability was dependent on the dendrimer concentration and duration of incubation. The correlation between monolayer permeability and the decrease in transepithelial electrical resistance (TEER) with both the PAMAM dendrimers and the polyamine-conjugated dendrimers suggests that paracellular transport is one of the mechanisms of transport across the epithelial cells. Cytotoxicity of the polyamine-conjugated dendrimers was evaluated in Caco-2 cells by MTT (methylthiazoletetrazolium) assay. Arginine-conjugated dendrimers were slightly more toxic than PAMAM dendrimer as well as ornithine-conjugated dendrimers. Though investigations on the possible involvement of other transport mechanisms are in progress, results of the present study suggest the potential of dendrimer-polyamine conjugates as drug carriers to increase the oral absorption of drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.