ArticleEuropean journal of nuclear medicine and molecular imaging2008
Determinants of the response of left ventricular ejection fraction to vasodilator stress in electrocardiographically gated (82)rubidium myocardial perfusion PET.
Article in European journal of nuclear medicine and molecular imaging, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Prognostic implications of post-stress ejection fraction decrease detected by gated SPECT in the absence of stress-induced perfusion abnormalities.European journal of nuclear medicine and molecular imaging · 2011Trial
- Exploratory Evaluation of Quantitative Rubidium-82 PET Myocardial Perfusion Parameters: Absolute Blood Flow, Flow Reserve, and Left Ventricular Function in an Arabian Gulf Cohort.Journal of clinical medicine · 2026Article
- Prognostic value of the left ventricular ejection fraction reserve acquired by gated myocardial perfusion SPECT in patients with CAD and reduced stress LVEF.Frontiers in cardiovascular medicine · 2024Article
- Dose-consistent dynamic SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic value of early left ventricular ejection fraction reserve during regadenoson stress solid-state SPECT-MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Left ventricular ejection fraction, myocardial blood flow and hemodynamic variables in adenosine and regadenoson vasodilator 82-Rubidium PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Gating Approaches in Cardiac PET Imaging.PET clinics · 2019Review
- Interpreting the change in left ventricular ejection fraction during pharmacological coronary vasodilation: Proceed with caution!Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Myocardial blood flow and left ventricular functional reserve in hypertrophic cardiomyopathy: aEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Left ventricular function in response to dipyridamole stress: head-to-head comparison betweenEuropean journal of nuclear medicine and molecular imaging · 2017Article
- Cardiac PET perfusion: prognosis, risk stratification, and clinical management.Seminars in nuclear medicine · 2014Review
- The relationship between ischemia-induced left ventricular dysfunction, coronary flow reserve, and coronary steal on regadenoson stress-gated (82)Rb PET myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Detection of obstructive coronary artery disease using regadenoson stress and 82Rb PET/CT myocardial perfusion imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2013Article
- ⁸²Rb PET myocardial perfusion imaging is superior to ⁹⁹mTc-labelled agent SPECT in patients with known or suspected coronary artery disease.European journal of nuclear medicine and molecular imaging · 2012Article
- Ischemic changes on rubidium-82 positron emission tomography imaging are associated with left ventricular functional and volumetric change independent of metabolic properties and echocardiographic functional variables in ischemic cardiomyopathy.The international journal of cardiovascular imaging · 2012Article
- Clinical Role of Hybrid Imaging.Current cardiovascular imaging reports · 2010Article
- Assessment of myocardial perfusion and function with PET and PET/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Review
- Incremental prognostic value of gated Rb-82 positron emission tomography myocardial perfusion imaging over clinical variables and rest LVEF.JACC. Cardiovascular imaging · 2009Article
- Integrated PET/CT in the assessment of etiology and viability in ischemic heart failure.Current heart failure reports · 2008Review
- Present and future of clinical cardiovascular PET imaging in Europe--a position statement by the European Council of Nuclear Cardiology (ECNC).European journal of nuclear medicine and molecular imaging · 2008Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMyocardial perfusion imaging with (82)Rb PET allows for ECG-gated studies to be obtained early after radiotracer injection, capturing ventricular function close to peak pharmacologic action of dipyridamole. This is different from gated SPECT and may potentially provide additional diagnostic information. We sought to identify potential correlates of the PET-derived ejection fraction response to vasodilator stress.
methodsOne hundred ten consecutive patients undergoing (82)Rb PET myocardial perfusion imaging during evaluation for coronary artery disease were included. Using a GE Discovery STRx PET-CT scanner, ECG-gated images (eight bins) were obtained at rest and 4 min after dipyridamole infusion, 90 s after infusion of 1,480-2,220 MBq of (82)Rb. Summed rest, stress, and difference scores (SRS, SSS, and SDS) were determined using a five-point scoring system and 20-segment model. Ejection fraction was calculated using automated QGS software.
resultsSignificant reversibility (SDS > or = 4) was found in 23 patients (21%). Mean LVEF in all patients was 47 +/- 13% at rest and 53 +/- 13% during dipyridamole. LVEF increased in 89 patients, and decreased in 17 patients during vasodilation. The change in LVEF was inversely correlated with SDS (r = -0.26; p = 0.007). Additionally, it was inversely correlated with resting LVEF (r = -0.20; p = 0.03) and SSS (r = -0.25; p = 0.009). No significant correlations were observed with SRS, heart rate, blood pressure, age, hypertension, hypercholesterolemia, or pretest likelihood of disease. At multivariate regression analysis, SDS was an independent predictor of the change in LVEF.
conclusionsGated (82)Rb PET during pharmacologic stress allows for assessment of the functional response to vasodilation. The magnitude of LVEF increase is determined by stress perfusion/reversible perfusion defects. Functional response to hyperemia may thus be incorporated in future evaluations of diagnostic and prognostic algorithms based on (82)Rb PET.
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