Evidence map›Paper›PMID 17912368›Full record

ArticlePloS one2007

Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults.

Mark Tarnopolsky, Andrew Zimmer, Jeremy Paikin, Adeel Safdar, Alissa Aboud, Erin Pearce, Brian Roy, Timothy Doherty

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 49 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 8 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00473902 nacompletednot on this map

Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and Body Composition Following Resistance Exercise in Older Adults

TypeinterventionalSponsorHamilton Health Sciences CorporationRan2003 to 2004Enrolled39ConditionsSarcopeniaArmsTraining, Creatine Monohydrate, Conjugated Linoleic Acid
NCT02529046 nacompletednot on this map

Effect of Conjugated Linoleic Acid Associated With Aerobic Exercise on Body Fat and Lipid Profile in Obese Women: A Randomized, Double-blinded and Placebo-controlled Trial

TypeinterventionalSponsorUniversidade Estadual de LondrinaRan2007 to 2007Enrolled28ConditionsLipid Metabolism Disorders, ObesityArmsCLA, Placebo
NCT03536871 nacompletednot on this mapstarted 2018, after this paper: background citation

Exercise and Nutritional Supplementation for Aging and Sedentary Lifestyles

TypeinterventionalSponsorMcMaster UniversityRan2018 to 2019Enrolled45ConditionsSarcopenia, Healthy Elderly, Healthy YoungArmsmulti-nutrient supplement, Exercise
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 8 syntheses or guidelines pooled it, 148 citations in OpenAlex.

  1. Pooled it
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  4. Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
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  14. Creatine monohydrate supplementation for older adults and clinical populations.Journal of the International Society of Sports Nutrition · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mark TarnopolskyDepartment of Pediatrics and Medicine, McMaster University, Hamilton, Ontario, Canada. tarnopol@mcmaster.ca
Andrew Zimmer
Jeremy Paikin
Adeel Safdar
Alissa Aboud
Erin Pearce
Brian Roy
Timothy Doherty
McMaster University · CABrock University · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with lower muscle mass and an increase in body fat. We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (>65 y). Men (N = 19) and women (N = 20) completed six months of resistance exercise training with CrM (5g/d)+CLA (6g/d) or placebo with randomized, double blind, allocation. Outcomes included: strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (Nu-telopeptides). Exercise training improved all measurements of functional capacity (P<0.05) and strength (P<0.001), with greater improvement for the CrM+CLA group in most measurements of muscular endurance, isokinetic knee extension strength, FFM, and lower fat mass (P<0.05). Plasma creatinine (P<0.05), but not creatinine clearance, increased for CrM+CLA, with no changes in serum CK activity or liver function tests. Together, this data confirms that supervised resistance exercise training is safe and effective for increasing strength in older adults and that a combination of CrM and CLA can enhance some of the beneficial effects of training over a six-month period. Trial Registration. ClinicalTrials.gov NCT00473902.

Indexed as

AgedAged, 80 and overAgingBody CompositionCreatineExerciseFemaleHumansIsometric ContractionLinoleic AcidMaleMusclesNutritional SciencesPhysical EnduranceWeight LiftingCreatineLinoleic Acid

Identifiers

PMID17912368
PMCPMC1994592
OpenAlexW1990601449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.