ReviewEpilepsia2007
Epileptogenesis in the developing brain: what can we learn from animal models?
Review in Epilepsia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- NaInternational journal of molecular sciences · 2022Article
- Prolonged Febrile Seizures Impair Synaptic Plasticity and Alter Developmental Pattern of Glial Fibrillary Acidic Protein (GFAP)-Immunoreactive Astrocytes in the Hippocampus of Young Rats.International journal of molecular sciences · 2022Article
- Glutamatergic System is Affected in Brain from an Hyperthermia-Induced Seizures Rat Model.Cellular and molecular neurobiology · 2022Article
- Early Life Events and Maturation of the Dentate Gyrus: Implications for Neurons and Glial Cells.International journal of molecular sciences · 2022Review
- Early Life Febrile Seizures Impair Hippocampal Synaptic Plasticity in Young Rats.International journal of molecular sciences · 2021Article
- Birth characteristics and risk of febrile seizures.Acta neurologica Scandinavica · 2021Article
- On the origin of ultraslow spontaneous NaJournal of neurophysiology · 2021Article
- Antiepileptogenic Effect of Retinoic Acid.Current neuropharmacology · 2021Article
- Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs.Neurochemical research · 2017Review
- Prolonged or recurrent acute seizures after pediatric arterial ischemic stroke are associated with increasing epilepsy risk.Developmental medicine and child neurology · 2017Article
- Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential.Frontiers in physiology · 2015Review
- IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.Frontiers in cellular neuroscience · 2013Article
- Neuronal injury and cytogenesis after simple febrile seizures in the hippocampal dentate gyrus of juvenile rat.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Uncovering the neurobehavioural comorbidities of epilepsy over the lifespan.Lancet (London, England) · 2012Review
- Neurotropic viral infections leading to epilepsy: focus on Theiler's murine encephalomyelitis virus.Future virology · 2011Article
- Is neuronal death necessary for acquired epileptogenesis in the immature brain?Epilepsy currents · 2010Article
- Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2010Article
- Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis.The American journal of pathology · 2010Article
- Early NMDA receptor-driven waves of activity in the developing neocortex: physiological or pathological network oscillations?The Journal of physiology · 2010Review
- Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats.Neurobiology of disease · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Knowledge of the processes by which epilepsy is generated (epileptogenesis) is incomplete and has been a topic of major research efforts. Animal models can inform us about these processes. We focus on the distinguishing features of epileptogenesis in the developing brain and model prolonged febrile seizures (FS) that are associated with human temporal lobe epilepsy. In the animal model of FS, epileptogenesis occurs in approximately 35% of rats. Unlike the majority of acquired epileptogeneses in adults, this process early in life (in the febrile seizures model as well as in several others) does not require "damage" (cell death). Rather, epileptogenesis early in life involves molecular mechanisms including seizure-evoked, long-lasting alterations of the expression of receptors and ion channels. Whereas transient changes in gene expression programs are common after early-life seizures, enduring effects, such as found after experimental FS, are associated with epileptogenesis. The ability of FS to generate long-lasting molecular changes and epilepsy suggests that mechanisms, including cytokine activation that are intrinsic to FS generation, may play a role also in the epileptogenic consequences of these seizures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.