ArticleBreast cancer research and treatment2008
Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans.
Article in Breast cancer research and treatment, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Benign breast disease and breast cancer risk in African women: a case-control study.Cancer causes & control : CCC · 2024Article
- The African Female Breast Cancer Epidemiology Study Protocol.Frontiers in oncology · 2022Article
- Drug-metabolizing enzymes: role in drug resistance in cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Review
- A Review of Cancer Genetics and Genomics Studies in Africa.Frontiers in oncology · 2020Review
- Uridine diphosphate glucuronosyl transferase 1A (UGT1A1) promoter polymorphism in young patients with sickle cell anaemia: report of the first cohort study from Nigeria.BMC medical genetics · 2019Article
- Prevalence of theCancer health disparities · 2019Article
- Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms.Xenobiotica; the fate of foreign compounds in biological systems · 2017Article
- Breast cancer risk after full-term pregnancies among African women from Nigeria, Cameroon, and Uganda.Cancer · 2015Article
- A comprehensive examination of breast cancer risk loci in African American women.Human molecular genetics · 2014Article
- Alcohol consumption and breast cancer risk among women in three sub-Saharan African countries.PloS one · 2014Article
- Phase two steroid metabolism and its roles in breast and prostate cancer patients.Frontiers in endocrinology · 2013Review
- The effect of UGT1A1 promoter polymorphism in the development of hyperbilirubinemia and cholelithiasis in hemoglobinopathy patients.PloS one · 2013Article
- Article
- Inter and intra-ethnic differences in the distribution of the molecular variants of TPMT, UGT1A1 and MDR1 genes in the South Indian population.Molecular biology reports · 2012Article
- Evaluation of 19 susceptibility loci of breast cancer in women of African ancestry.Carcinogenesis · 2012Article
- Characterization of UDP-glucuronosyltransferase (UGT1A1) Promoter Polymorphisms and Gene Expression on Ethnicity, Stage of Disease, and Menopausal Status in Breast Cancer.Journal of drug metabolism & toxicology · 2012Article
- Parity and breastfeeding are protective against breast cancer in Nigerian women.British journal of cancer · 2008Article
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
The UDP-glucuronosylatransferase 1A1 (UGT1A1) gene is involved in the metabolism of estrogen and detoxification of potential carcinogens. The number of TA repeats in the promoter region of UGT1A1 has been linked to breast cancer risk, but results varied by race. We performed a comprehensive assessment of genetic polymorphisms in the UGT1A1 gene, and examined these polymorphisms and TA repeats in relation to breast cancer risk in a case-control study in Nigeria. 512 breast cancer cases and 226 community controls were genotyped for UGT1A1. Compared with high-activity TA repeat genotypes, the odds ratios (OR) for low-activity and moderate-activity genotypes were 0.47 (95% confidence interval CI, 0.26-0.83) and 0.64 (95% CI, 0.39-1.06), respectively, in premenopausal women (P = 0.009 for trend), but no association was observed in postmenopausal women (P = 0.24). The effect of TA repeats was also differentiated by age: the OR was 0.39 (95% CI 0.21-0.71) for low-activity genotypes and 0.58 (95% CI 0.33-1.00) for moderate-activity genotypes in women <45 years old (P = 0.002 for trend), but no association was observed in women >or=45 years old (P = 0.15). Haplotype analysis showed that UGT1A1 haplotypes were highly diverse with blocked structures. We found a specific haplotype in block 2 that was significantly associated with a 2.1-fold elevated risk (95% CI 1.05-4.39; P = 0.04). In contrast with previous studies, we found low-activity TA repeat alleles were protective against breast cancer among premenopausal indigenous Africans, suggesting that the role of UGT1A1 in breast cancer development may vary by population, presumably due to different environmental and genetic modifier effects.
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