ArticleChromosoma2008
Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.
Article in Chromosoma, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 70 citations in OpenAlex.
- Tumor-suppressive activities of SA1/STAG2 and effects of PARP impairment during brain development.Disease models & mechanisms · 2026Article
- Linking Genotype to Clinical Features inGenes · 2025Review
- An RNAi screen to identify proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytes.G3 (Bethesda, Md.) · 2024Article
- The Green Valley ofCells · 2022Review
- Divergent Gene Expression Following Duplication of Meiotic Genes in the Stick Insect Clitarchus hookeri.Genome biology and evolution · 2021Article
- Case Report: Prenatal Whole-Exome Sequencing to Identify a Novel Heterozygous Synonymous Variant in NIPBL in a Fetus With Cornelia de Lange Syndrome.Frontiers in genetics · 2021Article
- The Drosophila MLR COMPASS complex is essential for programming cis-regulatory information and maintaining epigenetic memory during development.Nucleic acids research · 2020Article
- Cohesin occupancy and composition at enhancers and promoters are linked to DNA replication origin proximity inGenome research · 2019Article
- MiR-187-3p Enhances Propranolol Sensitivity of Hemangioma Stem Cells.Cell structure and function · 2019Article
- Article
- Behavioral and psychiatric manifestations in Cornelia de Lange syndrome.Current opinion in psychiatry · 2017Review
- Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation.Current biology : CB · 2016Article
- Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.PLoS genetics · 2015Article
- Complex elaboration: making sense of meiotic cohesin dynamics.The FEBS journal · 2015Review
- Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation.PLoS genetics · 2014Article
- Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I.Chromosoma · 2014Article
- Cell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The Drosophila enhancer of split gene complex: architecture and coordinate regulation by notch, cohesin, and polycomb group proteins.G3 (Bethesda, Md.) · 2013Article
- Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase.Cell division · 2013Article
- Cohesin and polycomb proteins functionally interact to control transcription at silenced and active genes.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Drosophila Nipped-B is an essential protein that has multiple functions. It facilitates expression of homeobox genes and is also required for sister chromatid cohesion. Nipped-B is conserved from yeast to man, and its orthologs also play roles in deoxyribonucleic acid repair and meiosis. Mutation of the human ortholog, Nipped-B-Like (NIPBL), causes Cornelia de Lange syndrome (CdLS), associated with multiple developmental defects. The Nipped-B protein family is required for the cohesin complex that mediates sister chromatid cohesion to bind to chromosomes. A key question, therefore, is whether the Nipped-B family regulates gene expression, meiosis, and development by controlling cohesin. To gain insights into Nipped-B's functions, we compared the effects of several Nipped-B mutations on gene expression, sister chromatid cohesion, and meiosis. We also examined association of Nipped-B and cohesin with somatic and meiotic chromosomes by immunostaining. Missense Nipped-B alleles affecting the same HEAT repeat motifs as CdLS-causing NIPBL mutations have intermediate effects on both gene expression and mitotic chromatid cohesion, linking these two functions and the role of NIPBL in human development. Nipped-B colocalizes extensively with cohesin on chromosomes in both somatic and meiotic cells and is present in soluble complexes with cohesin subunits in nuclear extracts. In meiosis, Nipped-B also colocalizes with the synaptonemal complex and contributes to maintenance of meiotic chromosome cores. These results support the idea that direct regulation of cohesin function underlies the diverse functions of Nipped-B and its orthologs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.