Trial reportPsychopharmacology2008
Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness.
Trial report in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06213883 (Characterizing Acute Exercise Response in Restrictive Eating Disorders), which is not on this map. Cited by 123 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing Acute Exercise Response in Restrictive Eating Disorders
Who cites it
123 citing papers in PubMed, 2 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Differential Associations of Dopamine and Serotonin With Reward and Punishment Processes in Humans: A Systematic Review and Meta-Analysis.JAMA psychiatry · 2025Pooled it
- COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.Genes, brain, and behavior · 2016Pooled it
- Computationally Informed Insights Into Anhedonia and Treatment by Kappa Opioid Receptor Antagonism.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Trial
- The effects of pramipexole on motivational vigour during a saccade task: a placebo-controlled study in healthy adults.Psychopharmacology · 2024Trial
- Trial
- Enhanced Taste Recognition Following Subacute Treatment With The Dopamine D2/D3 Receptor Agonist Pramipexole in Healthy Volunteers.The international journal of neuropsychopharmacology · 2022Trial
- Impaired Learning From Negative Feedback in Stimulant Use Disorder: Dopaminergic Modulation.The international journal of neuropsychopharmacology · 2021Trial
- A Causal Role for Gastric Rhythm in Human Disgust Avoidance.Current biology : CB · 2021Trial
- Pretreatment Reward Sensitivity and Frontostriatal Resting-State Functional Connectivity Are Associated With Response to Bupropion After Sertraline Nonresponse.Biological psychiatry · 2020Trial
- A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.Nature medicine · 2020Trial
- A neurocomputational account of reward and novelty processing and effects of psychostimulants in attention deficit hyperactivity disorder.Brain : a journal of neurology · 2018Trial
- Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Trial
- Establishing moderators and biosignatures of antidepressant response in clinical care (EMBARC): Rationale and design.Journal of psychiatric research · 2016Trial
- Levodopa impairs probabilistic reversal learning in healthy young adults.Psychopharmacology · 2016Trial
- The effect of a dopamine antagonist on conditioning of sexual arousal in women.Psychopharmacology · 2016Trial
- Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Dopamine, urges to smoke, and the relative salience of drug versus non-drug reward.Social cognitive and affective neuroscience · 2015Trial
- Role of dopamine D2 receptors in human reinforcement learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Effects of pramipexole on the processing of rewarding and aversive taste stimuli.Psychopharmacology · 2013Trial
- Dopamine-related deficit in reward learning after catecholamine depletion in unmedicated, remitted subjects with bulimia nervosa.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
rationaleThe dopaminergic system, particularly D2-like dopamine receptors, has been strongly implicated in reward processing. Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans.
objectivesTo evaluate the effect of a single, low dose of a D2/D3 agonist--pramipexole--on reinforcement learning in healthy adults. Based on prior evidence indicating that low doses of DA agonists decrease phasic DA release through autoreceptor stimulation, we hypothesized that 0.5 mg of pramipexole would impair reward learning due to presynaptic mechanisms. MATERIALS AND
methodsUsing a double-blind design, a single 0.5-mg dose of pramipexole or placebo was administered to 32 healthy volunteers, who performed a probabilistic reward task involving a differential reinforcement schedule as well as various control tasks.
resultsAs hypothesized, response bias toward the more frequently rewarded stimulus was impaired in the pramipexole group, even after adjusting for transient adverse effects. In addition, the pramipexole group showed reaction time and motor speed slowing and increased negative affect; however, when adverse physical side effects were considered, group differences in motor speed and negative affect disappeared.
conclusionsThese findings show that a single low dose of pramipexole impaired the acquisition of reward-related behavior in healthy participants, and they are consistent with prior evidence suggesting that phasic DA signaling is required to reinforce actions leading to reward. The potential implications of the present findings to psychiatric conditions, including depression and impulse control disorders related to addiction, are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.