ArticleThe Journal of cell biology2007
SMK-1/PPH-4.1-mediated silencing of the CHK-1 response to DNA damage in early C. elegans embryos.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- DAF-16 and SMK-1 Contribute to Innate Immunity During Adulthood inG3 (Bethesda, Md.) · 2020Article
- Article
- ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline.PLoS genetics · 2014Article
- PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression.The EMBO journal · 2012Article
- What goes on must come off: phosphatases gate-crash the DNA damage response.Trends in biochemical sciences · 2011Review
- The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair.PLoS genetics · 2010Article
- EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity.Cell metabolism · 2010Article
- A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.Nature structural & molecular biology · 2010Article
- Article
- The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo.Genetics · 2009Article
- Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans.Molecular cell · 2008Article
- Chromatin reassembly signals the end of DNA repair.Cell cycle (Georgetown, Tex.) · 2008Review
Corrections and comments
- Correction · 2009-02-23Error in Data · Error in Image · · Correction not individually indexed in Pubmed. 1/30/2017
- Retraction · 2010-06-28Error in Data · Error in Methods · Error in Results and/or Conclusions · Unreliable Results and/or Conclusions · · 1/30/2017
- Erratum issued
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
During early embryogenesis in Caenorhabditis elegans, the ATL-1-CHK-1 (ataxia telangiectasia mutated and Rad3 related-Chk1) checkpoint controls the timing of cell division in the future germ line, or P lineage, of the animal. Activation of the CHK-1 pathway by its canonical stimulus DNA damage is actively suppressed in early embryos so that P lineage cell divisions may occur on schedule. We recently found that the rad-2 mutation alleviates this checkpoint silent DNA damage response and, by doing so, causes damage-dependent delays in early embryonic cell cycle progression and subsequent lethality. In this study, we report that mutations in the smk-1 gene cause the rad-2 phenotype. SMK-1 is a regulatory subunit of the PPH-4.1 (protein phosphatase 4) protein phosphatase, and we show that SMK-1 recruits PPH-4.1 to replicating chromatin, where it silences the CHK-1 response to DNA damage. These results identify the SMK-1-PPH-4.1 complex as a critical regulator of the CHK-1 pathway in a developmentally relevant context.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.