ArticleBMC genomics2007
DNA copy number profiles of gastric cancer precursor lesions.
Article in BMC genomics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Chromosomal Instability in Gastric Cancer: Role in Tumor Development, Progression, and Therapy.International journal of molecular sciences · 2023Review
- Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Characterization of human gastric adenocarcinoma cell lines established from peritoneal ascites.Oncology letters · 2018Article
- Clinical significance of NOTCH1 intracellular cytoplasmic domain translocation into the nucleus in gastric cancer.Biomedical reports · 2016Article
- Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma.Molecular cytogenetics · 2016Article
- The association between DNA copy number aberrations at chromosome 5q22 and gastric cancer.PloS one · 2014Article
- Detection limits of DNA copy number alterations in heterogeneous cell populations.Cellular oncology (Dordrecht, Netherlands) · 2013Article
- Pyloric gland adenoma of the cystic duct with malignant transformation: report of a case with a review of the literature.BMC cancer · 2012Article
- Genetic aspects of gastric cancer instability.TheScientificWorldJournal · 2012Review
- Duodenal adenocarcinoma arising from a pyloric gland adenoma with a brief review of the literature.BMJ case reports · 2010Review
- High resolution analysis of DNA copy-number aberrations of chromosomes 8, 13, and 20 in gastric cancers.Virchows Archiv : an international journal of pathology · 2009Article
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundChromosomal instability (CIN) is the most prevalent type of genomic instability in gastric tumours, but its role in malignant transformation of the gastric mucosa is still obscure. In the present study, we set out to study whether two morphologically distinct categories of gastric cancer precursor lesions, i.e. intestinal-type and pyloric gland adenomas, would carry different patterns of DNA copy number changes, possibly reflecting distinct genetic pathways of gastric carcinogenesis in these two adenoma types.
resultsUsing a 5K BAC array CGH platform, we showed that the most common aberrations shared by the 11 intestinal-type and 10 pyloric gland adenomas were gains of chromosomes 9 (29%), 11q (29%) and 20 (33%), and losses of chromosomes 13q (48%), 6(48%), 5(43%) and 10 (33%). The most frequent aberrations in intestinal-type gastric adenoma were gains on 11q, 9q and 8, and losses on chromosomes 5q, 6, 10 and 13, whereas in pyloric gland gastric adenomas these were gains on chromosome 20 and losses on 5q and 6. However, no significant differences were observed between the two adenoma types.
conclusionThe results suggest that gains on chromosomes 8, 9q, 11q and 20, and losses on chromosomes 5q, 6, 10 and 13, likely represent early events in gastric carcinogenesis. The phenotypical entities, intestinal-type and pyloric gland adenomas, however, do not differ significantly (P = 0.8) at the level of DNA copy number changes.
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