ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
Genome-wide search for markers associated with osteochondrosis in Hanoverian warmblood horses.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 46 citations in OpenAlex.
- Defining the Impact of Genetics on Equine Performance and Development of Orthopaedic Disease.Animals : an open access journal from MDPI · 2026Review
- Osteochondrosis in horses: An overview of genetic and other factors.Equine veterinary journal · 2026Review
- Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era.Animal genetics · 2019Review
- Emerging genetic basis of osteochondritis dissecans.Clinics in sports medicine · 2014Review
- Articular osteochondrosis: a comparison of naturally-occurring human and animal disease.Osteoarthritis and cartilage · 2013Review
- A genome-wide association study of osteochondritis dissecans in the Thoroughbred.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs.BMC genetics · 2010Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
A genome-wide scan was performed to detect quantitative trait loci (QTLs) for osteochondrosis (OC) and osteochondrosis dissecans (OCD) in horses. The marker set comprised 260 microsatellites. We collected data from 211 Hanoverian warmblood horses consisting of 14 paternal half-sib families. Traits used were OC (fetlock and/or hock joints affected), OCD (fetlock and/or hock joints affected), fetlock OC, fetlock OCD, hock OC, and hock OCD. The first genome scan included 172 microsatellite markers. In a second step 88 additional markers were chosen to refine putative QTLs found in the first scan. Genome-wide significant QTLs were located on equine chromosomes 2, 4, 5, and 16. QTLs for fetlock OC and hock OC partly overlapped on the same chromosomes, indicating that these traits may be genetically related. QTLs reached the chromosome-wide significance level on eight different equine chromosomes: 2, 3, 4, 5, 15, 16, 19, and 21. This whole-genome scan was a first step toward the identification of candidate genome regions harboring genes responsible for equine OC. Further investigations are necessary to refine the map positions of the QTLs already identified for OC.
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Registered trials
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