ArticleOncogene2008
High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells.
Article in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment.Journal of hematology & oncology · 2024Review
- Isoproterenol Alters Metabolism, Promotes Survival and Migration in 5-Fluorouracil-Treated SW480 Cells with and without Beta-hydroxybutyrate.International journal of molecular and cellular medicine · 2023Article
- Review
- ACBD3 Bioinformatic Analysis and Protein Expression in Breast Cancer Cells.International journal of molecular sciences · 2022Article
- Article
- Complex roles of cAMP-PKA-CREB signaling in cancer.Experimental hematology & oncology · 2020Review
- Protein Kinase A Distribution in Meningioma.Cancers · 2019Article
- The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines.Journal of experimental & clinical cancer research : CR · 2017Article
- miR-200c dampens cancer cell migration via regulation of protein kinase A subunits.Oncotarget · 2015Article
- The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment.Cancers · 2014Article
- Targeting protein kinase A in cancer therapy: an update.EXCLI journal · 2014Review
- Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas.British journal of cancer · 2013Article
- PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.Nature communications · 2013Article
- PKA regulatory subunit R2B is required for murine and human adipocyte differentiation.Endocrine connections · 2013Article
- Soluble adenylyl cyclase antibody profile as a diagnostic adjunct in the assessment of pigmented lesions.Archives of dermatology · 2012Article
- Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger.Acta physiologica (Oxford, England) · 2012Review
- The differential diagnosis of familial lentiginosis syndromes.Familial cancer · 2011Review
- Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model.BMC cancer · 2011Article
- Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function.Cellular and molecular life sciences : CMLS · 2011Article
- Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes.BMC bioinformatics · 2009Article
Corrections and comments
- Retraction · 2025-07-28Concerns/Issues about Data · Concerns/Issues about Image · Duplication of/in Image · Euphemisms for Duplication · Investigation by Third Party · Unreliable Data · · See also: https://pubpeer.com/publications/0657E5E48076726F56BD38CA5B8259
- Retracted
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cAMP-protein kinase A (PKA) pathway is the major signal transduction pathway involved in melanocyte-stimulating hormone receptor-mediated signaling and melanin production, whereas its role in the control of melanocyte proliferation is still controversial. In this study, we evaluated the effects of selective activation of the different PKA regulatory subunits type 1A (R1A) and type 2B (R2B) on melanocyte proliferation. Immunohistochemistry demonstrated that normal melanocytes lacked R1A protein whereas this subunit was highly expressed in all human melanomas studied (N=20) and in six human melanoma cell lines. Pharmacological activation of the R2 subunits by the cAMP analogue 8-Cl-cAMP inhibited proliferation and increased caspase-3 activity by 68.77+/-10.5 and 72+/-9% respectively, in all cell lines with the exception of the only p53-mutated one. Similar effects were obtained by activating R2 subunits with other analogues and by silencing R1A expression. The antiproliferative and proapoptotic effects of 8-Cl-cAMP were comparable to those observed with commonly used antitumoral drugs. Moreover, 8-Cl-cAMP potentiated the effects of these drugs on both cell proliferation and caspase-3 activity. In conclusion, this study first reports that human melanomas are characterized by a high R1/R2 ratio and that pharmacological and genetic manipulations able to revert this unbalanced expression cause significant antiproliferative and proapoptotic effects in melanoma cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.