ArticleEukaryotic cell2007
Developmental commitment in Dictyostelium discoideum.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- A New Classification Framework to Understand Evolutionary Transitions in Individuality.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Meiosis-associated expression patterns during starvation-induced cell fusion in the protist Fisculla terrestris.BMC biology · 2025Article
- mTORC1 pathway activity biases cell fate choice.Scientific reports · 2024Article
- Prestalk-like positioning of de-differentiated cells in the social amoeba Dictyostelium discoideum.Scientific reports · 2024Article
- Procedures to Measure Dictyostelium Phagocytosis and Macropinocytosis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Collective signalling drives rapid jumping between cell states.Development (Cambridge, England) · 2023Article
- Starvation Induces Extracellular Accumulation of Polyphosphate inInternational journal of molecular sciences · 2023Article
- An interplay of resource availability, population size and mutation rate potentiates the evolution of metabolic signaling.BMC ecology and evolution · 2021Article
- Article
- IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Controlling organism size by regulating constituent cell numbers.Proceedings of the ... IEEE Conference on Decision & Control. IEEE Conference on Decision & Control · 2018Article
- The physiological regulation of macropinocytosis duringJournal of cell science · 2018Article
- Fat-containing cells are eliminated duringBiology open · 2017Article
- A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Asymmetric nanotopography biases cytoskeletal dynamics and promotes unidirectional cell guidance.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Fitness tradeoffs between spores and nonaggregating cells can explain the coexistence of diverse genotypes in cellular slime molds.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Identification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach.Molecular and cellular biochemistry · 2014Article
- An evolutionarily significant unicellular strategy in response to starvation in Dictyostelium social amoebae.F1000Research · 2014Article
- Reproductive competence: a recurrent logic module in eukaryotic development.Proceedings. Biological sciences · 2013Review
- Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses.Journal of cell science · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Upon starvation, Dictyostelium discoideum cells halt cell proliferation, aggregate into multicellular organisms, form migrating slugs, and undergo morphogenesis into fruiting bodies while differentiating into dormant spores and dead stalk cells. At almost any developmental stage cells can be forced to dedifferentiate when they are dispersed and diluted into nutrient broth. However, migrating slugs can traverse lawns of bacteria for days without dedifferentiating, ignoring abundant nutrients and continuing development. We now show that developing Dictyostelium cells revert to the growth phase only when bacteria are supplied during the first 4 to 6 h of development but that after this time, cells continue to develop regardless of the presence of food. We postulate that the cells' inability to revert to the growth phase after 6 h represents a commitment to development. We show that the onset of commitment correlates with the cells' loss of phagocytic function. By examining mutant strains, we also show that commitment requires extracellular cyclic AMP (cAMP) signaling. Moreover, cAMP pulses are sufficient to induce both commitment and the loss of phagocytosis in starving cells, whereas starvation alone is insufficient. Finally, we show that the inhibition of development by food prior to commitment is independent of contact between the cells and the bacteria and that small soluble molecules, probably amino acids, inhibit development during the first few hours and subsequently the cells become unable to react to the molecules and commit to development. We propose that commitment serves as a checkpoint that ensures the completion of cooperative aggregation of developing Dictyostelium cells once it has begun, dampening the response to nutritional cues that might inappropriately block development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.