ArticleThe Plant cell2007
Oryza sativa dicer-like4 reveals a key role for small interfering RNA silencing in plant development.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed, 156 citations in OpenAlex.
- Silencing Suppressor Protein p26 of Areca Palm Velarivirus 1 (APV1) Interacts With SGS3 and Promotes Its Degradation Via the Ubiquitination Pathway.Molecular plant pathology · 2026Article
- Spatiotemporal regulation of target mRNA cleavage by 21-nt phasiRNAs in maize anthers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Non-conserved microRNAs and their roles in plants: the case for legumes.Plant biology (Stuttgart, Germany) · 2025Review
- Sexual reproduction in land plants: an evolutionary perspective.Plant reproduction · 2025Review
- Article
- The OsSGS3-tasiRNA-OsARF3 module orchestrates abiotic-biotic stress response trade-off in rice.Nature communications · 2023Article
- The TaTCP4/10-B1 cascade regulates awn elongation in wheat (Triticum aestivum L.).Plant communications · 2023Article
- Phylogenetic analyses of seven protein families refine the evolution of small RNA pathways in green plants.Plant physiology · 2023Article
- CRISPR/Cas9-targeted mutagenesis of TaDCL4, TaDCL5 and TaRDR6 induces male sterility in common wheat.Plant biotechnology journal · 2023Article
- Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Small RNA and Degradome Sequencing in Floral Bud Reveal Roles of miRNAs in Dormancy Release ofInternational journal of molecular sciences · 2023Article
- Article
- A spontaneous thermo-sensitive female sterility mutation in rice enables fully mechanized hybrid breeding.Cell research · 2022Article
- Diverse ecological functions and the convergent evolution of grass awns.American journal of botany · 2022Review
- RNAi-Based Antiviral Innate Immunity in Plants.Viruses · 2022Review
- TRANS-ACTING SIRNA3-derived short interfering RNAs confer cleavage of mRNAs in rice.Plant physiology · 2022Article
- An atypical class of non-coding small RNAs is produced in rice leaves upon bacterial infection.Scientific reports · 2021Article
- Metatranscriptomic Sequencing Suggests the Presence of Novel RNA Viruses in Rice Transmitted by Brown Planthopper.Viruses · 2021Article
- A novel Transposable element-derived microRNA participates in plant immunity to rice blast disease.Plant biotechnology journal · 2021Article
- Degradome sequencing-based identification of phasiRNAs biogenesis pathways in Oryza sativa.BMC genomics · 2021Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs and small interfering RNAs (siRNAs) are two classes of small regulatory RNAs derived from different types of precursors and processed by distinct Dicer or Dicer-like (DCL) proteins. During evolution, four Arabidopsis thaliana DCLs and six rice (Oryza sativa) DCLs (Os DCLs) appear to have acquired specialized functions. The Arabidopsis DCLs are well characterized, but those in rice remain largely unstudied. Here, we show that both knockdown and loss of function of rice DCL4, the homolog of Arabidopsis DCL4, lead to vegetative growth abnormalities and severe developmental defects in spikelet identity. These phenotypic alterations appear to be distinct from those observed in Arabidopsis dcl4 mutants, which exhibit accelerated vegetative phase change. The difference in phenotype between rice and Arabidopsis dcl4 mutants suggests that siRNA processing by DCL4 has a broader role in rice development than in Arabidopsis. Biochemical and genetic analyses indicate that Os DCL4 is the major Dicer responsible for the 21-nucleotide siRNAs associated with inverted repeat transgenes and for trans-acting siRNA (ta-siRNA) from the endogenous TRANS-ACTING siRNA3 (TAS3) gene. We show that the biogenesis mechanism of TAS3 ta-siRNA is conserved but that putative direct targets of Os DCL4 appear to be differentially regulated between monocots and dicots. Our results reveal a critical role of Os DCL4-mediated ta-siRNA biogenesis in rice development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.