ArticleBiophysical journal2008
Phase behavior of a model bilayer membrane with coupled leaves.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The Importance of Bilayer Asymmetry in Biological Membranes: Insights from Model Membranes.Membranes · 2025Review
- Article
- Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences.Cold Spring Harbor perspectives in biology · 2023Review
- Experimentally determined leaflet-leaflet phase diagram of an asymmetric lipid bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Physical Concept to Explain the Regulation of Lipid Membrane Phase Separation under Isothermal Conditions.Life (Basel, Switzerland) · 2023Review
- Sensing a little friction.Biophysical journal · 2022Article
- Lattice Models for Protein Organization throughout Thylakoid Membrane Stacks.Biophysical journal · 2020Article
- Role of Transmembrane Proteins for Phase Separation and Domain Registration in Asymmetric Lipid Bilayers.Biomolecules · 2019Article
- Effects of Passive Phospholipid Flip-Flop and Asymmetric External Fields on Bilayer Phase Equilibria.Biophysical journal · 2018Article
- Roles of Interleaflet Coupling and Hydrophobic Mismatch in Lipid Membrane Phase-Separation Kinetics.Journal of the American Chemical Society · 2016Article
- Relaxation dynamics of two-component fluid bilayer membranes.The European physical journal. E, Soft matter · 2016Article
- Registered and antiregistered phase separation of mixed amphiphilic bilayers.Biophysical journal · 2015Article
- Macroscopic phase separation, modulated phases, and microemulsions: a unified picture of rafts.Biophysical journal · 2014Article
- Interleaflet coupling and domain registry in phase-separated lipid bilayers.Biophysical journal · 2011Article
- Theory of raft formation by the cross-linking of saturated or unsaturated lipids in model lipid bilayers.Biophysical journal · 2009Article
- Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations.Biophysical journal · 2009Article
- An introduction to critical points for biophysicists; observations of compositional heterogeneity in lipid membranes.Biochimica et biophysica acta · 2009Review
- Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures.Biochimica et biophysica acta · 2009Review
- Membrane domain formation, interdigitation, and morphological alterations induced by the very long chain asymmetric C24:1 ceramide.Biophysical journal · 2008Article
- Interleaflet coupling mechanisms in bilayers of lipids and cholesterol.Biophysical journal · 2008Article
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2 authors.
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Abstract
We discuss the thermodynamic behavior of a bilayer composed of two coupled leaves and derive the Gibbs Phase Rule for such a system. A simple phenomenological model of such a system is considered in which the state of the bilayer is specified by the relative number of ordering lipids in the outer leaf, and in the inner leaf. Two cases are treated. In the first, both inner and outer leaves could undergo phase separation when uncoupled from one another. The bilayer can exist in four different phases, and can exhibit three-phase coexistence. In the second case, an outer layer which can undergo phase separation by itself is coupled to an inner leaf which cannot. We find that when the coupling is weak, the bilayer can exist in only two phases, one in which the outer layer is rich in ordering lipids and the inner leaf is somewhat richer in them than when uncoupled, and another in which the outer layer is poor in ordering lipids and the inner leaf is poorer in them than when uncoupled. Increasing the coupling increases the effect on the inner leaf composition due to small changes in those of the outer leaf. For sufficiently large coupling, a phase transition occurs and the bilayer exhibits four phases as in the first case considered. Our results are in accord with several observations made recently.
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