ArticleJournal of immunological methods2007
Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay.
Article in Journal of immunological methods, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Hepatitis E virus: from innate sensing to adaptive immune responses.Nature reviews. Gastroenterology & hepatology · 2024Review
- Immunobiology and Host Response to HEV.Advances in experimental medicine and biology · 2023Article
- Viral hepatitis in pregnancy.Journal of viral hepatitis · 2022Review
- Hepatitis E Infection in a Longitudinal Cohort of Hepatitis C Virus and HCV/HIV Coinfected Persons.AIDS research and human retroviruses · 2021Article
- Adaptive Immune Responses in Hepatitis A Virus and Hepatitis E Virus Infections.Cold Spring Harbor perspectives in medicine · 2019Review
- Clinical features and determinants of chronicity in hepatitis E virus infection.Journal of viral hepatitis · 2019Review
- Analysis of IgG Anti-HEV Antibody Protective Levels During Hepatitis E Virus Reinfection in Experimentally Infected Rhesus Macaques.The Journal of infectious diseases · 2019Article
- Hepatitis E virus: advances and challenges.Nature reviews. Gastroenterology & hepatology · 2018Review
- Serum Levels of Soluble CD26, A Novel Prognostic Marker for Hepatitis E Infection.Jundishapur journal of microbiology · 2016Article
- Design and production of a multiepitope construct derived from hepatitis E virus capsid protein.Journal of medical virology · 2015Article
- Swine is a possible source of hepatitis E virus infection by comparative study of hepatitis A and E seroprevalence in Thailand.PloS one · 2015Article
- Modulation of HCV replication after combination antiretroviral therapy in HCV/HIV co-infected patients.Science translational medicine · 2014Article
- Autochthonous hepatitis e virus infections: a new transfusion-associated risk?Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2014Review
- Cross reactive cellular immune response to HCV genotype 1 and 4 antigens among genotype 4 exposed subjects.PloS one · 2014Article
- Host immune status and response to hepatitis E virus infection.Clinical microbiology reviews · 2014Review
- Diagnosis of hepatitis E.Nature reviews. Gastroenterology & hepatology · 2013Review
- Hepatitis C virus-specific cell-mediated immune responses in children born to mothers infected with hepatitis C virus.The Journal of pediatrics · 2013Article
- Hepatitis E virus infection in HIV-infected patients with elevated serum transaminases levels.Virology journal · 2011Article
- Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children.The Journal of infectious diseases · 2011Article
- Risk factors and immune response to hepatitis E viral infection among acute hepatitis patients in Assiut, Egypt.The Egyptian journal of immunology · 2010Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
Abstract
In developing countries, hepatitis E (HEV) and hepatitis A (HAV) are the major causes of acute viral hepatitis with similar feco-oral modes of transmission. In contrast to the high seroprevalence of hepatitis A infection, a low seroprevalence of HEV among children in endemic areas has been reported. These data suggest the possibility that silent HEV infection is undiagnosed by the current available methods. Many of the serological tests used for HEV diagnosis have poor specificity and are unable to differentiate among different genotypes of HEV. Moreover, the RT-PCR used for HEV isolation is only valid for a brief period during the acute stage of infection. Cell-mediated immune (CMI) responses are highly sensitive, and long lasting after sub-clinical infections as shown in HCV and HIV. Our objective was to develop a quantitative assay for cell-mediated immune (CMI) responses in HEV infection as a surrogate marker for HEV exposure in silent infection. Quantitative assessment of the CMI responses in HEV will also help us to evaluate the role of CMI in HEV morbidity. In this study, an HEV-specific interferon-gamma (IFN-gamma) ELISPOT assay was optimized to analyze HEV-specific CMI responses. We used peripheral blood mononuclear cells (PBMC) and sera from experimentally infected chimpanzees and from seroconverted and control human subjects to validate the assay. The HEV-specific IFN-gamma ELISPOT responses correlated strongly and significantly with anti-HEV ELISA positive/negative results (rho=0.73, p=0.02). Moreover, fine specificities of HEV-specific T cell responses could be identified using overlapping HEV ORF2 peptides.
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Registered trials
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