ReviewNeurobiology of learning and memory2008
Protein synthesis inhibitors, gene superinduction and memory: too little or too much protein?
Review in Neurobiology of learning and memory, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Cpeb1 remodels cell type-specific translational program to promote fear extinction.Science advances · 2025Article
- Stress-induced nuclear speckle reorganization is linked to activation of immediate early gene splicing.The Journal of cell biology · 2023Article
- Spatiotemporally resolved protein synthesis as a molecular framework for memory consolidation.Trends in neurosciences · 2022Review
- Synapse integrity and function: Dependence on protein synthesis and identification of potential failure points.Frontiers in molecular neuroscience · 2022Article
- Electroconvulsive Shock Does Not Impair the Reconsolidation of Cued and Contextual Pavlovian Threat Memory.International journal of molecular sciences · 2020Article
- Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.Nature neuroscience · 2020Article
- Emotional Modulation of Learning and Memory: Pharmacological Implications.Pharmacological reviews · 2017Review
- Updating Procedures Can Reorganize the Neural Circuit Supporting a Fear Memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Consolidation of altered associability information by amygdala central nucleus.Neurobiology of learning and memory · 2016Article
- Spermidine-induced improvement of reconsolidation of memory involves calcium-dependent protein kinase in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning.Neurobiology of learning and memory · 2015Article
- The amygdala is critical for trace, delay, and contextual fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Molecular mechanisms underlying formation of long-term reward memories and extinction memories in the honeybee (Apis mellifera).Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Cycloheximide impairs and enhances memory depending on dose and footshock intensity.Behavioural brain research · 2012Article
- Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala.Neurobiology of learning and memory · 2011Article
- p38 mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide.Journal of neurochemistry · 2011Article
- Molecular specificity of multiple hippocampal processes governing fear extinction.Reviews in the neurosciences · 2010Review
- Intrahippocampal infusions of anisomycin produce amnesia: contribution of increased release of norepinephrine, dopamine, and acetylcholine.Learning & memory (Cold Spring Harbor, N.Y.) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To date, the effects of protein synthesis inhibitors (PSI) in learning and memory processes have been attributed to translational arrest and consequent inhibition of de novo protein synthesis. Here we argue that amnesia produced by PSI can be the direct result of their abnormal induction of mRNA-a process termed gene superinduction. This action exerted by PSI involves an abundant and prolonged accumulation of mRNA transcripts of genes that are normally transiently induced. We summarize experimental evidence for the multiple mechanisms and signaling pathways mediating gene superinduction and consider its relevance for PSI-induced amnesia. This mechanistic alternative to protein synthesis inhibition is compared to models of electroconvulsive seizures and fragilexsyndrome associated with enhanced mRNA/protein levels and cognitive deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.