ReviewBMC neuroscience2007
Co-regulation of a large and rapidly evolving repertoire of odorant receptor genes.
Review in BMC neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Olfactory receptor coding sequences cause silencing of episomal constructs in multiple cell lines.Molecular and cellular neurosciences · 2021Article
- Article
- Two highly related odorant receptors specifically detect α-bile acid pheromones in sea lamprey (The Journal of biological chemistry · 2020Article
- Review
- Comparative Genomic Analysis of the Pheromone Receptor Class 1 Family (V1R) Reveals Extreme Complexity in Mouse Lemurs (Genus, Microcebus) and a Chromosomal Hotspot across Mammals.Genome biology and evolution · 2020Article
- A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity.PLoS genetics · 2016Article
- Article
- Combinatorial rules of precursor specification underlying olfactory neuron diversity.Current biology : CB · 2013Article
- Differentiation of developing olfactory neurons analysed in terms of coupled epigenetic landscapes.Nucleic acids research · 2013Article
- Article
- Uncoupling stimulus specificity and glomerular position in the mouse olfactory system.Molecular and cellular neurosciences · 2012Article
- Personal receptor repertoires: olfaction as a model.BMC genomics · 2012Article
- Functional evolution of mammalian odorant receptors.PLoS genetics · 2012Article
- On-Center/Inhibitory-Surround Decorrelation via Intraglomerular Inhibition in the Olfactory Bulb Glomerular Layer.Frontiers in integrative neuroscience · 2012Article
- Article
- EvoluCode: Evolutionary Barcodes as a Unifying Framework for Multilevel Evolutionary Data.Evolutionary bioinformatics online · 2012Article
- Long non-coding RNAs in nervous system function and disease.Brain research · 2010Review
- Ecological adaptation determines functional mammalian olfactory subgenomes.Genome research · 2010Article
- YY1's DNA-binding motifs in mammalian olfactory receptor genes.BMC genomics · 2009Article
- Plasticity of the chemoreceptor repertoire in Drosophila melanogaster.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The olfactory system meets niche- and species-specific demands by an accelerated evolution of its odorant receptor repertoires. In this review, we describe evolutionary processes that have shaped olfactory and vomeronasal receptor gene families in vertebrate genomes. We emphasize three important periods in the evolution of the olfactory system evident by comparative genomics: the adaptation to land in amphibian ancestors, the decline of olfaction in primates, and the delineation of putative pheromone receptors concurrent with rodent speciation. The rapid evolution of odorant receptor genes, the sheer size of the repertoire, as well as their wide distribution in the genome, presents a developmental challenge: how are these ever-changing odorant receptor repertoires coordinated within the olfactory system? A central organizing principle in olfaction is the specialization of sensory neurons resulting from each sensory neuron expressing only ~one odorant receptor allele. In this review, we also discuss this mutually exclusive expression of odorant receptor genes. We have considered several models to account for co-regulation of odorant receptor repertoires, as well as discussed a new hypothesis that invokes important epigenetic properties of the system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.