ReviewBMC neuroscience2007
The sense of smell, its signalling pathways, and the dichotomy of cilia and microvilli in olfactory sensory cells.
Review in BMC neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Modelling Olfactory Dysfunction in Rodents Through Intranasal Vanadium Exposure.Animals : an open access journal from MDPI · 2026Review
- Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.Developmental cell · 2024Article
- Validity and Reliability of the Malay Questionnaire for Olfactory Disorders.The Malaysian journal of medical sciences : MJMS · 2023Article
- Zinc Oxide Nanoparticles (ZnO-NPs) Induce Cytotoxicity in the Zebrafish Olfactory Organs via Activating Oxidative Stress and Apoptosis at the Ultrastructure and Genetic Levels.Animals : an open access journal from MDPI · 2023Article
- The morphological and functional diversity of apical microvilli.Journal of anatomy · 2023Review
- Removal of cellular protrusions.Seminars in cell & developmental biology · 2022Review
- Olfactory dysfunction in patients with cluster headache.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Modulation of olfactory signal detection in the olfactory epithelium: focus on the internal and external environment, and the emerging role of the immune system.Cell and tissue research · 2021Review
- Charging Up the Periphery: Glial Ionic Regulation in Sensory Perception.Frontiers in cell and developmental biology · 2021Review
- Olfactory Rod Cells: A Rare Cell Type in the Larval Zebrafish Olfactory Epithelium With a Large Actin-Rich Apical Projection.Frontiers in physiology · 2021Article
- A Combined Study of Headspace Volatiles using Human Sensory, Mass Spectrometry and Chemometrics.Scientific reports · 2020Article
- Review
- Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling.Frontiers in immunology · 2020Review
- The ventral epithelium ofBiology open · 2019Article
- Olfactory receptor neuronal dendrites become mostly intra-sustentacularly enwrapped upon maturity.Journal of anatomy · 2018Article
- Sensational placodes: neurogenesis in the otic and olfactory systems.Developmental biology · 2014Review
- Kappe neurons, a novel population of olfactory sensory neurons.Scientific reports · 2014Article
- Distributed organization of a brain microcircuit analyzed by three-dimensional modeling: the olfactory bulb.Frontiers in computational neuroscience · 2014Article
- Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory function.PloS one · 2012Article
- The long and the short of aberrant ciliogenesis in Huntington disease.The Journal of clinical investigation · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smell is often regarded as an ancillary perception in primates, who seem so dominated by their sense of vision. In this paper, we will portray some aspects of the significance of olfaction to human life and speculate on what evolutionary factors contribute to keeping it alive. We then outline the functional architecture of olfactory sensory neurons and their signal transduction pathways, which are the primary detectors that render olfactory perception possible. Throughout the phylogenetic tree, olfactory neurons, at their apical tip, are either decorated with cilia or with microvilli. The significance of this dichotomy is unknown. It is generally assumed that mammalian olfactory neurons are of the ciliary type only. The existence of so-called olfactory microvillar cells in mammals, however, is well documented, but their nature remains unclear and their function orphaned. This paper discusses the possibility, that in the main olfactory epithelium of mammals ciliated and microvillar sensory cells exist concurrently. We review evidence related to this hypothesis and ask, what function olfactory microvillar cells might have and what signalling mechanisms they use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.