ArticleBreastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine2007
Longitudinal comparison of chemokines in breastmilk early postpartum among HIV-1-infected and uninfected Kenyan women.
Article in Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Recurrent Severe Subclinical Mastitis and the Risk of HIV Transmission Through Breastfeeding.Frontiers in immunology · 2022Trial
- Analysis of the TCR Repertoire in HIV-Exposed but Uninfected Infants.Scientific reports · 2019Trial
- High concentrations of interleukin 15 in breast milk are associated with protection against postnatal HIV transmission.The Journal of infectious diseases · 2009Trial
- Impact of Maternal Exposure to SARS-CoV-2 on Immunological Components of Breast Milk.International journal of molecular sciences · 2025Review
- Diabetes-preventive molecular mechanisms of breast versus formula feeding: new insights into the impact of milk on stem cell Wnt signaling.Frontiers in nutrition · 2025Review
- Immediate Pre-Partum SARS-CoV-2 Status and Immune Profiling of Breastmilk: A Case-Control Study.Frontiers in immunology · 2021Article
- Distribution of bioactive factors in human milk samples.International breastfeeding journal · 2019Article
- The immune response to sub-clinical mastitis is impaired in HIV-infected women.Journal of translational medicine · 2018Article
- HIV-exposed uninfected infants: elevated cord blood Interleukin 8 (IL-8) is significantly associated with maternal HIV infection and systemic IL-8 in a Kenyan cohort.Clinical and translational medicine · 2018Article
- Subclinical mastitis occurs frequently in association with dramatic changes in inflammatory/anti-inflammatory breast milk components.Pediatric research · 2017Article
- Breastfeeding Behaviors and the Innate Immune System of Human Milk: Working Together to Protect Infants against Inflammation, HIV-1, and Other Infections.Frontiers in immunology · 2017Review
- Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques.PLoS pathogens · 2014Article
- Immunology of pediatric HIV infection.Immunological reviews · 2013Review
- Upregulation of innate antiviral restricting factor expression in the cord blood and decidual tissue of HIV-infected mothers.PloS one · 2013Article
- Breast milk cellular HIV-specific interferon γ responses are associated with protection from peripartum HIV transmission.AIDS (London, England) · 2012Article
- The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk.PloS one · 2011Article
- Primary human mammary epithelial cells endocytose HIV-1 and facilitate viral infection of CD4+ T lymphocytes.Journal of virology · 2010Article
- CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission.International journal of immunogenetics · 2010Article
- Breastfeeding in HIV-positive women: What can be recommended?Paediatric drugs · 2010Article
- The detection of cytomegalovirus DNA in maternal plasma is associated with mortality in HIV-1-infected women and their infants.AIDS (London, England) · 2009Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Breastmilk chemokines have been associated with increased HIV-1 RNA levels in breastmilk and altered risk of mother-to-child HIV-1 transmission. To characterize CC and CXC chemokines in breastmilk postpartum, we collected breastmilk specimens at regular intervals for 6 months after delivery from women with and without HIV-1 infection and used commercial ELISA kits to measure breastmilk concentrations of MIP-1alpha, MIP-1beta, RANTES, and SDF-1alpha. Among 54 HIV-1-infected and 26 uninfected women, mean chemokine levels were compared cross-sectionally and longitudinally at days 5 and 10, and months 1 and 3 postpartum. For both HIV-1-infected and uninfected women, breastmilk chemokine levels were highest at day 5 for MIP-1alpha, MIP-1beta, and SDF-1alpha, and subsequently decreased. RANTES levels remained constant over the follow-up period among HIV-1-uninfected women, and increased moderately among HIV-1-infected women. For MIP-1beta and RANTES, breastmilk levels were significantly higher among HIV-1-infected women compared to uninfected women early postpartum. In addition, HIV-1-infected women transmitting HIV-1 to their infant had consistently higher breastmilk RANTES levels than those who did not transmit, with the greatest difference observed at 1 month (2.68 vs. 2.21 log10 pg/mL, respectively; p = 0.007). In summary, all four chemokines were most elevated within the first month postpartum, a period of high transmission risk via breastmilk. MIP-1beta and RANTES levels in breastmilk were higher among HIV-1-infected women than among uninfected women, and breastmilk RANTES was positively associated with vertical transmission in this study, consistent with results from our earlier cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.