ArticleEuropean archives of psychiatry and clinical neuroscience2007
White matter hyperintensities and their associations with suicidality in patients with major affective disorders.
Article in European archives of psychiatry and clinical neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- The association between white matter hyperintensities and suicide attempts in affective disorders: a systematic review and meta-analysis.Translational psychiatry · 2025Pooled it
- White matter hyperintensities and their association with suicidality in major affective disorders: a meta-analysis of magnetic resonance imaging studies.CNS spectrums · 2010Pooled it
- Hyperintense MRI lesions in bipolar disorder: A meta-analysis and review.International review of psychiatry (Abingdon, England) · 2009Pooled it
- Edge-centric brain connectomes reveal two molecularly distinct neurobiological subtypes of adolescent major depressive disorder.European child & adolescent psychiatry · 2026Article
- Plasma Apo-E mediated corticospinal tract abnormalities and suicidality in patients with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Altered Levels of Plasma Inflammatory Cytokines and White Matter Integrity in Bipolar Disorder Patients With Suicide Attempts.Frontiers in psychiatry · 2022Article
- Brain Functional and Structural Alterations in Women With Bipolar Disorder and Suicidality.Frontiers in psychiatry · 2021Article
- Bipolar Disorder and Suicide: a Review.Current psychiatry reports · 2020Review
- Increased Amygdala-Paracentral Lobule/Precuneus Functional Connectivity Associated With Patients With Mood Disorder and Suicidal Behavior.Frontiers in human neuroscience · 2020Article
- White matter abnormalities of corpus callosum in patients with bipolar disorder and suicidal ideation.Annals of general psychiatry · 2019Article
- Neuroimaging Studies of Suicidal Behavior and Non-suicidal Self-Injury in Psychiatric Patients: A Systematic Review.Frontiers in psychiatry · 2018Article
- Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk.Current psychiatry reports · 2017Review
- Cerebral White Matter Lesions and Affective Episodes Correlate in Male Individuals with Bipolar Disorder.PloS one · 2015Article
- White matter abnormalities: Insights into the pathophysiology of major affective disorders.World journal of radiology · 2014Article
- Is there a neuroanatomical basis of the vulnerability to suicidal behavior? A coordinate-based meta-analysis of structural and functional MRI studies.Frontiers in human neuroscience · 2014Article
- Differences between suicide attempters and nonattempters in depressed older patients: depression severity, white-matter lesions, and cognitive functioning.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2014Article
- Enlarged thalamic volumes and increased fractional anisotropy in the thalamic radiations in veterans with suicide behaviors.Frontiers in psychiatry · 2013Article
- Total white matter hyperintensity volume in bipolar disorder patients and their healthy relatives.Bipolar disorders · 2012Article
- White matter hyperintensities and self-reported depression in a sample of patients with chronic headache.The journal of headache and pain · 2012Article
- Relationship between suicidality and impulsivity in bipolar I disorder: a diffusion tensor imaging study.Bipolar disorders · 2012Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA large body of evidence suggests that predisposition to suicide, an important public health problem, is mediated to a certain extent by neurobiological factors. The objective of this cross-sectional study was to compare the prevalence of white matter hyperintensities (WMH) in patients with major affective disorders with and without histories of suicide attempts.
methodsT2-weighted magnetic resonance images (MRI) of 65 psychiatric inpatients with major depressive disorder or bipolar disorder were rated for the presence of WMH. Diagnoses, presence or absence of suicide risk and substance abuse were determined by the Mini International Neuropsychiatric Interview (MINI). Medical charts were reviewed to ascertain history of suicide attempt and basic clinical variables. Fisher's Exact Tests and logistic regression modeling were used to test the association between WMH and suicidality. Suicidal patients and controls were not matched for demographic variables and exposure to some risk factors.
resultsBivariate analysis showed that the prevalence of WMH was significantly higher in subjects with past suicide attempts (Fisher's Exact Test, p = 0.01) and other clinical indicators of elevated suicide risk. Logistic regression analyses controlling for age, sex, and several clinical risk factors supported this finding (odds ratio = 4.7; 95% confidence interval: 1.4, 16.1).
conclusionsThe increased prevalence of WMH in adults with major affective disorders and a history of suicide attempt, compared to similar patients without such a history, is consistent with previous findings in depressed children, youth and young adults. However, the association between WMH and suicidality holds true for both, depressed and bipolar patients. Our results suggest that WMH in patients with major affective disorders might be useful biological markers of suicidality.
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