ArticleHuman genetics2008
CFTR mutations and reproductive outcomes in a population isolate.
Article in Human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- The Impact of Cystic Fibrosis Algorithm Changes: A Case Study of Challenges and Strategies.International journal of neonatal screening · 2025Article
- Clinical Phenotypes of Cystic Fibrosis Carriers.Annual review of medicine · 2022Review
- Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis.Chemical reviews · 2019Article
- Article
- A common spinal muscular atrophy deletion mutation is present on a single founder haplotype in the US Hutterites.European journal of human genetics : EJHG · 2011Article
- Haplotypes versus genotypes on pedigrees.Algorithms for molecular biology : AMB · 2011Article
- The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate.PLoS genetics · 2010Article
- Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes.European journal of human genetics : EJHG · 2010Article
- Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.Genetic epidemiology · 2010Article
- A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.The Laryngoscope · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Multiple hypotheses have been proposed to explain the high incidence of cystic fibrosis in Caucasian populations. Most rely on a fitness advantage to carriers of CF mutations, either through increased resistance to infectious disease, such as cholera, or through increased fertility. In this study we tested the latter hypothesis in the Hutterites of South Dakota, a genetic isolate with a relatively high CF carrier frequency. Following a population-wide screen for the only two mutations present in the Hutterites (M1101K, DeltaF508), we tested for associations between carrier status and measures of fertility. There was no evidence of nonrandom transmission of mutations (P = 0.409) or skewed sex ratios (P = 0.847) in children of carrier parents. Moreover, carrier status was not associated with overall fertility (P = 0.597 for carrier fathers and 0.694 for carrier mothers). Although carrier males' sibship sizes were larger than carrier females' sibship sizes (P = 0.049), this was not significant after accounting for multiple testing. Overall, our results suggest that if there is a fertility advantage among CF carriers, it is too small to be detected in our sample (85 carriers out of approximately 950 screened), or the effects are confined to DeltaF508 carriers, for which there are too few in our sample to test this specific hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.