ArticleDiabetologia2007
Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease.
Article in Diabetologia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 95 citations in OpenAlex.
- Article
- Histone modification in podocyte injury of diabetic nephropathy.Journal of molecular medicine (Berlin, Germany) · 2022Review
- Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy.Clinical and translational medicine · 2021Article
- Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway.Drug design, development and therapy · 2020Article
- Inhibition of P53/miR-34a improves diabetic endothelial dysfunction via activation of SIRT1.Journal of cellular and molecular medicine · 2019Article
- Nephropathy induced by renal microembolism: a characterization of biochemical and histopathological changes in rats.International journal of clinical and experimental pathology · 2019Article
- The role of sirolimus in proteinuria in diabetic nephropathy rats.Iranian journal of basic medical sciences · 2017Article
- LY333531, a PKCβ inhibitor, attenuates glomerular endothelial cell apoptosis in the early stage of mouse diabetic nephropathy via down-regulating swiprosin-1.Acta pharmacologica Sinica · 2017Article
- PLK2 Plays an Essential Role in High D-Glucose-Induced Apoptosis, ROS Generation and Inflammation in Podocytes.Scientific reports · 2017Article
- Semiautomated quantitative image analysis of glomerular immunohistochemistry markers desmin, vimentin, podocin, synaptopodin and WT-1 in acute and chronic rat kidney disease models.Histochemistry and cell biology · 2016Article
- Combined Microencapsulated Islet Transplantation and Revascularization of Aortorenal Bypass in a Diabetic Nephropathy Rat Model.Journal of diabetes research · 2016Article
- Sirtuin 1: A Target for Kidney Diseases.Molecular medicine (Cambridge, Mass.) · 2015Review
- Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes.Journal of diabetes investigation · 2015Review
- Enhanced epithelial-to-mesenchymal transition associated with lysosome dysfunction in podocytes: role of p62/Sequestosome 1 as a signaling hub.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2015Article
- Early-onset diabetic E1-DN mice develop albuminuria and glomerular injury typical of diabetic nephropathy.BioMed research international · 2015Article
- Mycophenolate mofetil inhibits hypertrophy and apoptosis of podocyte in vivo and in vitro.International journal of clinical and experimental medicine · 2015Article
- Podocytes, signaling pathways, and vascular factors in diabetic kidney disease.Advances in chronic kidney disease · 2014Review
- Repeated systemic administration of human adipose-derived stem cells attenuates overt diabetic nephropathy in rats.Stem cells and development · 2013Article
- The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo.American journal of physiology. Renal physiology · 2013Article
- Podocyte repopulation by renal progenitor cells following glucocorticoids treatment in experimental FSGS.American journal of physiology. Renal physiology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisPodocyte loss by apoptosis, in addition to favouring progression of established diabetic nephropathy, has been recently indicated as an early phenomenon triggering the initiation of glomerular lesions. This study aimed to assess the rate of glomerular cell death and its relationship with renal functional, structural and molecular changes in rats with experimental diabetes.
methodsMale Sprague-Dawley rats with streptozotocin-induced diabetes and coeval non-diabetic control animals were killed at 7 days and at 2, 4 and 6 months for the assessment of apoptosis, renal function, renal structure and the expression of podocyte markers and apoptosis- and cell cycle-related proteins.
resultsGlomerular cell apoptosis was significantly increased in diabetic vs non-diabetic rats at 4 months and to an even greater extent at 6 months, with podocytes accounting for 70% of apoptosing cells. The increase in apoptosis was preceded by increases in proteinuria, albuminuria and mean glomerular and mesangial areas, and by reductions in glomerular cell density and content of synaptopodin and Wilms' tumour protein-1. It coincided with the development of mesangial expansion and glomerular sclerosis, and with the upregulation/activation both of tumour protein p53, which increased progressively throughout the study, and of p21 (also known as cyclin-dependent kinase inhibitor 1A, CIP1 and WAF1), which peaked at 4 months and decreased thereafter. CONCLUSIONS/
interpretationGlomerular cell (podocyte) apoptosis is not an early feature in the course of experimental diabetic glomerulopathy, since it is preceded by glomerular hypertrophy, which may decrease glomerular cell density to the point of inducing compensatory podocyte hypertrophy. This is associated with reduced podocyte protein expression (podocytopathy) and proteinuria, and ultimately results in apoptotic cell loss (podocytopenia), driving progression to mesangial expansion and glomerular sclerosis.
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