ArticleGenetica2008
Identification of the female-determining region of the W chromosome in Bombyx mori.
Article in Genetica, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- The complete sequence of the silkworm W chromosome uncovers its rapid evolution by large-scale duplications/deletions and translocation of W-linked genes.G3 (Bethesda, Md.) · 2026Article
- The Sex Determination Cascade in the Silkworm.Genes · 2021Review
- Gtsf1 is essential for proper female sex determination and transposon silencing in the silkworm, Bombyx mori.PLoS genetics · 2020Article
- Proteotranscriptomics assisted gene annotation and spatial proteomics of Bombyx mori BmN4 cell line.BMC genomics · 2020Article
- A Novel Splice Variant of the Masculinizing GeneBiomolecules · 2019Article
- Alternative splicing regulation of doublesex gene by RNA-binding proteins in the silkworm Bombyx mori.RNA biology · 2019Article
- Silkworm genetic sexing through W chromosome-linked, targeted gene integration.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The genome of the Hi5 germ cell line fromeLife · 2018Article
- FeminizingEvolution letters · 2017Article
- Two Conserved Cysteine Residues Are Required for the Masculinizing Activity of the Silkworm Masc Protein.The Journal of biological chemistry · 2015Article
- Article
- Anatomical and functional analysis of domestication effects on the olfactory system of the silkmoth Bombyx mori.Proceedings. Biological sciences · 2014Article
- Guardian small RNAs and sex determination.RNA biology · 2014Article
- Linkage map of the peppered moth, Biston betularia (Lepidoptera, Geometridae): a model of industrial melanism.Heredity · 2013Article
- Altered expression of testis-specific genes, piRNAs, and transposons in the silkworm ovary masculinized by a W chromosome mutation.BMC genomics · 2012Article
- The silkworm W chromosome is a source of female-enriched piRNAs.RNA (New York, N.Y.) · 2011Article
- Cloning and identification of a female-specific DNA marker in Paramisgurnus dabryanus.Fish physiology and biochemistry · 2011Article
- Article
- Use of a regulatory mechanism of sex determination in pest insect control.Journal of genetics · 2010Article
- Molecular analysis of sex chromosome-linked mutants in the silkworm Bombyx mori.Journal of genetics · 2010Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The W chromosome of the silkworm Bombyx mori is devoid of functional genes, except for the putative female-determining gene (Fem). To localize Fem, we investigated the presence of W-specific DNA markers on strains in which an autosomal fragment containing dominant marker genes was attached to the W chromosome. We produced new W-chromosomal fragments from the existing Zebra-W strain (T(W;3)Ze chromosome) by X-irradiation, and then carried out deletion mapping of these and sex-limited yellow cocoon strains (T(W;2)Y-Chu, -Abe and -Ban types) from different Japanese stock centers. Of 12 RAPD markers identified in the normal W chromosomes of most silkworm strains in Japan, the newly irradiated W(B-YL-YS)Ze chromosome contained three, the T(W;2)Y-Chu chromosome contained six, and the T(W;2)Y-Abe and -Ban chromosomes contained only one (W-Rikishi). To investigate the ability of the reduced W-chromosome translocation fragments to form heterochromatin bodies, which are found in nuclei of normal adult female sucking stomachs, we examined cells of the normal type p50 strain and the T(W;2)Y-Chu and -Abe strains. A single sex heterochromatin body was found in nuclei of p50 females, whereas we detected only small sex heterochromatin bodies in the T(W;2)Y-Chu strain and no sex heterochromatin body in the T(W;2)Y-Abe strain. Since adult females of all strains were normal and fertile, we conclude that only extremely limited region, containing the W-Rikishi RAPD sequence of the W chromosome, is required to determine femaleness. Based on a comparison of the normal W-chromosome and 7 translocation and W-deletion strains we present a map of Fem relative to the 12 W-specific RAPD markers.
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