Trial reportStroke2007
Lesion volume change after treatment with tissue plasminogen activator can discriminate clinical responders from nonresponders.
Trial report in Stroke, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke.Nature communications · 2021Trial
- Final cerebral infarct volume is predictable by MR imaging at 1 week.AJNR. American journal of neuroradiology · 2011Trial
- In Mild and Moderate Acute Ischemic Stroke, Increased Lipid Peroxidation and Lowered Antioxidant Defenses Are Strongly Associated with Disabilities and Final Stroke Core Volume.Antioxidants (Basel, Switzerland) · 2023Article
- Time dependence in diffusion MRI predicts tissue outcome in ischemic stroke patients.Magnetic resonance in medicine · 2021Article
- Perfusion recovery on TTP maps after endovascular stroke treatment might predict favorable neurological outcomes.European radiology · 2020Article
- Diffusion-weighted imaging (DWI) ischemic volume is related to FLAIR hyperintensity-DWI mismatch and functional outcome after endovascular therapy.Quantitative imaging in medicine and surgery · 2020Article
- Diffusion Kurtosis Imaging of Acute Infarction: Comparison with Routine Diffusion and Follow-up MR Imaging.Radiology · 2018Article
- pH imaging reveals worsened tissue acidification in diffusion kurtosis lesion than the kurtosis/diffusion lesion mismatch in an animal model of acute stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Article
- Semi-automated method for estimating lesion volumes.Journal of neuroscience methods · 2013Article
- The presence of visual neglect after thrombolytic treatment in patients with right hemisphere stroke.TheScientificWorldJournal · 2012Article
- Imaging of acute stroke.Nature reviews. Neurology · 2010Review
- Can early ischemic lesion recurrence on diffusion-weighted MRI affect functional outcome after acute ischemic stroke?Journal of clinical neurology (Seoul, Korea) · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
background and purposeA change in acute-to-chronic lesion volume has been proposed as a biomarker for stroke therapies. The objectives of this study were to determine the magnitude of lesion volume change after standard treatment with tissue plasminogen activator and to determine whether specific volume change thresholds can discriminate clinical responders from nonresponders.
methodsWe measured lesion volume on diffusion weighted at baseline and on 90-day fluid attenuated inversion recovery MRI and scored 3-month modified Rankin Scale in consecutive patients treated with tissue plasminogen activator. We identified variables associated with excellent (modified Rankin Scale 0 to 1) and independent (modified Rankin Scale 0 to 2) outcomes.
resultsWe included 53 patients (mean age 69 years, median baseline National Institutes of Health Stroke Scale score 7). The mean acute-to-chronic lesion volume increase was 11.7 (+/-7.7) cm(3). In 23 patients, the chronic lesion was smaller than the baseline lesion. At 3 months, 32 patients had an excellent clinical outcome. Dichotomous volume change variables associated with outcome included decrease in volume >or=30% (P=0.004) and volume increase >or=5 cm(3) (P=0.002).
conclusionsIn patients given standard tissue plasminogen activator therapy, changes in lesion volume are associated with clinical outcome, and threshold lesion volumes can differentiate excellent and poor outcome, suggesting these as a potential marker of outcome.
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