Evidence map›Paper›PMID 17901227›Full record

ReviewEndocrinology2007

Minireview: The neuroendocrinology of the suprachiasmatic nucleus as a conductor of body time in mammals.

Ilia N Karatsoreos, Rae Silver

Open access · bronzeAbstract readReview
In one paragraph

Review in Endocrinology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 100 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Melatonin, Clock Genes, and Mammalian Reproduction: What Is the Link?International journal of molecular sciences · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Frontiers in endocrinology · 2017
    Article
  13. Neuroendocrine underpinnings of sex differences in circadian timing systems.The Journal of steroid biochemistry and molecular biology · 2016
    Review
  14. Article
  15. Article
  16. Article
  17. Minutes, days and years: molecular interactions among different scales of biological timing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ilia N KaratsoreosDepartment of Psychology, Columbia University, 406 Schermerhorn Hall, 1190 Amsterdam Avenue, New York, NY 10027, USA.
Rae Silver
Columbia University · US

Funding

PHYSIOLOGICAL DISSECTION OF THE SCNR01NS037919 · NINDS · BARNARD COLLEGE · PI SILVER, RAE · 1998 to 2010
$3.3M
NINDS NIH HHS NS 023224NINDS NIH HHS NS 37919NINDS NIH HHS R01 NS037919
6 · The paper itself

Abstract

Circadian rhythms in physiology and behavior are regulated by a master clock resident in the suprachiasmatic nucleus (SCN) of the hypothalamus, and dysfunctions in the circadian system can lead to serious health effects. This paper reviews the organization of the SCN as the brain clock, how it regulates gonadal hormone secretion, and how androgens modulate aspects of circadian behavior known to be regulated by the SCN. We show that androgen receptors are restricted to a core SCN region that receives photic input as well as afferents from arousal systems in the brain. We suggest that androgens modulate circadian behavior directly via actions on the SCN and that both androgens and estrogens modulate circadian rhythms through an indirect route, by affecting overall activity and arousal levels. Thus, this system has multiple levels of regulation; the SCN regulates circadian rhythms in gonadal hormone secretion, and hormones feed back to influence SCN functions.

Indexed as

AndrogensAnimalsCircadian RhythmEstrogensGonadal HormonesMammalsModels, BiologicalNeuroendocrinologySuprachiasmatic NucleusAndrogensEstrogensGonadal Hormones

Identifiers

PMID17901227
PMCPMC3423957
OpenAlexW2116272264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.