ArticleGenes & development2007
Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation.
Article in Genes & development, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement.Journal of cell science · 2021Article
- Extracellular heparan sulfate proteoglycans and glycan-binding lectins orchestrateJournal of cell science · 2020Review
- Synapse development and maturation at the drosophila neuromuscular junction.Neural development · 2020Review
- Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at theeLife · 2018Article
- Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis.Science signaling · 2017Article
- Activity-Induced Synaptic Structural Modifications by an Activator of Integrin Signaling at theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Matrix Metalloproteinase-9 Regulates Neuronal Circuit Development and Excitability.Molecular neurobiology · 2016Article
- Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model.Disease models & mechanisms · 2016Article
- The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis.Development (Cambridge, England) · 2016Article
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- Annotation and expression analysis of cuticular proteins from the tobacco hornworm, Manduca sexta.Insect biochemistry and molecular biology · 2015Article
- Prodomain removal enables neto to stabilize glutamate receptors at the Drosophila neuromuscular junction.PLoS genetics · 2015Article
- The matrix protein Hikaru genki localizes to cholinergic synaptic clefts and regulates postsynaptic organization in the Drosophila brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Two protein N-acetylgalactosaminyl transferases regulate synaptic plasticity by activity-dependent regulation of integrin signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- N-glycosylation requirements in neuromuscular synaptogenesis.Development (Cambridge, England) · 2013Article
- Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction.The Journal of cell biology · 2013Article
- Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis.Developmental neurobiology · 2012Article
- A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance.Developmental biology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Formation and regulation of excitatory glutamatergic synapses is essential for shaping neural circuits throughout development. In a Drosophila genetic screen for synaptogenesis mutants, we identified mind the gap (mtg), which encodes a secreted, extracellular N-glycosaminoglycan-binding protein. MTG is expressed neuronally and detected in the synaptic cleft, and is required to form the specialized transsynaptic matrix that links the presynaptic active zone with the post-synaptic glutamate receptor (GluR) domain. Null mtg embryonic mutant synapses exhibit greatly reduced GluR function, and a corresponding loss of localized GluR domains. All known post-synaptic signaling/scaffold proteins functioning upstream of GluR localization are also grossly reduced or mislocalized in mtg mutants, including the dPix-dPak-Dock cascade and the Dlg/PSD-95 scaffold. Ubiquitous or neuronally targeted mtg RNA interference (RNAi) similarly reduce post-synaptic assembly, whereas post-synaptically targeted RNAi has no effect, indicating that presynaptic MTG induces and maintains the post-synaptic pathways driving GluR domain formation. These findings suggest that MTG is secreted from the presynaptic terminal to shape the extracellular synaptic cleft domain, and that the cleft domain functions to mediate transsynaptic signals required for post-synaptic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.