ArticleProceedings of the National Academy of Sciences of the United States of America2007
Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 221 papers, 1 of them a synthesis that pooled it.
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Who cites it
221 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of data from spaceflight transcriptome experiments does not support the idea of a common bacterial "spaceflight response".Scientific reports · 2018Pooled it
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- Gravity as a Boundary Condition for the Evolution of Three-Dimensional Multicellularity.Life (Basel, Switzerland) · 2026Article
- Biofilms: from the cradle of life to life support.NPJ biofilms and microbiomes · 2026Review
- Microgravity-induced constraints on melanin bioproduction: investigating E. coli metabolic responses aboard the international space station.NPJ microgravity · 2026Article
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- Adaptive transcriptional remodeling ofNpj complexity · 2026Article
- Spaceflight and Medical Microbiology: Possible Implications for Standard Infection Diagnostics and Therapy.Life (Basel, Switzerland) · 2025Article
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- Touching Surfaces - Presence of microorganisms on antimicrobial metal surfaces on the International Space Station and in German schools.BMC microbiology · 2025Article
- Synthetic biology for space exploration.NPJ microgravity · 2025Review
- Genomic description ofmSystems · 2025Article
- Simulated microgravity triggers a membrane adaptation to stress in E. coli REL606.BMC microbiology · 2025Article
- Microgravity and Cellular Biology: Insights into Cellular Responses and Implications for Human Health.International journal of molecular sciences · 2025Review
- Article
- Developing an alternative medium for in-space biomanufacturing.Nature communications · 2025Article
- Evaluation of theFrontiers in bioengineering and biotechnology · 2025Article
161 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
41 authors.
Funding
Abstract
A comprehensive analysis of both the molecular genetic and phenotypic responses of any organism to the space flight environment has never been accomplished because of significant technological and logistical hurdles. Moreover, the effects of space flight on microbial pathogenicity and associated infectious disease risks have not been studied. The bacterial pathogen Salmonella typhimurium was grown aboard Space Shuttle mission STS-115 and compared with identical ground control cultures. Global microarray and proteomic analyses revealed that 167 transcripts and 73 proteins changed expression with the conserved RNA-binding protein Hfq identified as a likely global regulator involved in the response to this environment. Hfq involvement was confirmed with a ground-based microgravity culture model. Space flight samples exhibited enhanced virulence in a murine infection model and extracellular matrix accumulation consistent with a biofilm. Strategies to target Hfq and related regulators could potentially decrease infectious disease risks during space flight missions and provide novel therapeutic options on Earth.
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Registered trials
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