Trial reportThe Journal of physiology2007
Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans.
Trial report in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Radial Pulse and Electrocardiography Modulation by Mild Thermal Stresses Applied to Feet: An Exploratory Study with Randomized, Crossover Design.Chinese journal of integrative medicine · 2020Trial
- Normothermic central hypovolemia tolerance reflects hyperthermic tolerance.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Trial
- Acute volume expansion attenuates hyperthermia-induced reductions in cerebral perfusion during simulated hemorrhage.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Compression leggings modestly affect cardiovascular but not cerebrovascular responses to heat and orthostatic stress in young and older adults.Age (Dordrecht, Netherlands) · 2012Trial
- Colloid volume loading does not mitigate decreases in central blood volume during simulated haemorrhage while heat stressed.The Journal of physiology · 2012Trial
- Skin surface cooling improves orthostatic tolerance following prolonged head-down bed rest.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Trial
- Impact of peripheral skin cooling on neuroendocrine leukocytic and hematological reactions during Hypergravity.NPJ microgravity · 2025Article
- Drug Administration Before or After Exposure to Low Temperatures-Does It Matter for the Therapeutic Effect?International journal of molecular sciences · 2025Article
- Peripheral vasoconstriction is not elevated during hyperreactive responses to the cold pressor test: a cross-sectional study.Frontiers in physiology · 2025Article
- The Acute Effect of Hot Water Immersion on Cardiac Function in Individuals with Cervical Spinal Cord Injury.Journal of clinical medicine · 2024Article
- Heated environment increases blood pressure drop and postural sway during initial orthostasis in healthy subjects.European journal of applied physiology · 2024Article
- Moving in a hotter world: Maintaining adequate childhood fitness as a climate change countermeasure.Temperature (Austin, Tex.) · 2023Review
- Peripheral skin cooling during hyper-gravity: hemodynamic reactions.Frontiers in physiology · 2023Article
- Heat therapy: mechanistic underpinnings and applications to cardiovascular health.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Review
- Hemodynamics of post-exercise vs. post hot water immersion recovery.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Changes in electrocardiogram parameters during acute nonshivering cold exposure and associations with brown adipose tissue activity, plasma catecholamine levels, and brachial blood pressure in healthy adults.Physiological reports · 2021Article
- Post-exercise Body Cooling: Skin Blood Flow, Venous Pooling, and Orthostatic Intolerance.Frontiers in sports and active living · 2021Review
- Adaptive changes in physiological and perceptual responses during 10-day heat acclimation training using a water-perfused suit.Journal of physiological anthropology · 2020Article
- Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Central venous pressure (CVP) provides information regarding right ventricular filling pressure, but is often assumed to reflect left ventricular filling pressure. It remains unknown whether this assumption is correct during thermal challenges when CVP is elevated during skin-surface cooling or reduced during whole-body heating. The primary objective of this study was to test the hypothesis that changes in CVP reflect those in left ventricular filling pressure, as expressed by pulmonary capillary wedge pressure (PCWP), during lower-body negative pressure (LBNP) while subjects are normothermic, during skin-surface cooling, and during whole-body heating. In 11 subjects, skin-surface cooling was imposed by perfusing 16 degrees C water through a water-perfused suit worn by each subject, while heat stress was imposed by perfusing 47 degrees C water through the suit sufficient to increase internal temperature 0.95 +/- 0.07 degrees C (mean +/- s.e.m.). While normothermic, CVP was 6.3 +/- 0.2 mmHg and PCWP was 9.5 +/- 0.3 mmHg. These pressures increased during skin-surface cooling (7.8 +/- 0.2 and 11.1 +/- 0.3 mmHg, respectively; P < 0.05) and decreased during whole-body heating (3.6 +/- 0.1 and 6.5 +/- 0.2 mmHg, respectively; P < 0.05). The decrease in CVP with LBNP was correlated with the reduction in PCWP during normothermia (r = 0.93), skin-surface cooling (r = 0.91), and whole-body heating (r = 0.81; all P < 0.001). When these three thermal conditions were combined, the overall r value between CVP and PCWP was 0.92. These data suggest that in the assessed thermal conditions, CVP appropriately tracks left ventricular filling pressure as indexed by PCWP. The correlation between these values provides confidence for the use of CVP in studies assessing ventricular preload during thermal and combined thermal and orthostatic perturbations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.