Trial reportClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2007
Efficacy of on-demand asimadoline, a peripheral kappa-opioid agonist, in females with irritable bowel syndrome.
Trial report in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05900752 (A Multi-Strain Probiotic Reduces the Frequency of Diarrhea in IBS-D Patients), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-Strain Probiotic Reduces the Frequency of Diarrhea in IBS-D Patients: A Two-Center, Randomized, Double-Blind, Placebo-controlled Study
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Efficacy of opioid receptor modulators in patients with irritable bowel syndrome: A systematic review and meta-analysis.Medicine · 2021Pooled it
- Evidence-based clinical practice guidelines for irritable bowel syndrome.Journal of gastroenterology · 2015Guideline
- Multilevel analyses of on-demand medication data, with an application to the treatment of Female Sexual Interest/Arousal Disorder.PloS one · 2019Trial
- Asimadoline, a kappa-opioid agonist, and satiation in functional dyspepsia.Alimentary pharmacology & therapeutics · 2008Trial
- Irritable Bowel Syndrome Clinical Care Gaps and the Potential of Future Therapeutics Based on Peripheral Visceral Afferent Modulation.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Review
- Postoperative Pain Management in Patients With Ulcerative Colitis.Anesthesia progress · 2020Article
- Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design.Scientific reports · 2016Article
- New and emerging therapies for the treatment of irritable bowel syndrome: an update for gastroenterologists.Therapeutic advances in gastroenterology · 2016Review
- Treatment of abdominal pain in irritable bowel syndrome.Journal of gastroenterology · 2014Review
- Irritable bowel syndrome: current and emerging treatment options.P & T : a peer-reviewed journal for formulary management · 2014Article
- Abdominal bloating: pathophysiology and treatment.Journal of neurogastroenterology and motility · 2013Review
- New treatments for IBS.Nature reviews. Gastroenterology & hepatology · 2013Review
- Effects of peripheral κ opioid receptor activation on inflammatory mechanical hyperalgesia in male and female rats.Neuroscience letters · 2012Article
- Brain-gut axis: from basic understanding to treatment of IBS and related disorders.Journal of pediatric gastroenterology and nutrition · 2012Review
- Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.The Journal of pharmacology and experimental therapeutics · 2012Article
- Asimadoline and its potential for the treatment of diarrhea-predominant irritable bowel syndrome: a review.Clinical and experimental gastroenterology · 2012Article
- Stress and visceral pain: from animal models to clinical therapies.Experimental neurology · 2012Review
- Drug management of visceral pain: concepts from basic research.Pain research and treatment · 2012Article
- Psychopharmacological treatment and psychological interventions in irritable bowel syndrome.Gastroenterology research and practice · 2012Article
- Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents.Therapeutic advances in gastroenterology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsIn experimental animal models of irritable bowel syndrome (IBS) and human studies, peripheral kappa opioid agonists have been shown to decrease sensation to colonic distention. The aim of this study was to compare the effects of the kappa opioid agonist, asimadoline, and placebo on episodes of abdominal pain in patients with IBS.
methodsAfter a 2-week run-in period, 100 patients with IBS were randomized (3:2 ratio) to receive asimadoline, up to 1 mg 4 times daily, or placebo for 4 weeks in a double-blind study. Pain was scored by daily diary using a 100-mm visual analogue scale. During pain episodes, patients recorded the pain severity, took study medication, and recorded their pain score 2 hours later. The primary end point was the average reduction in pain severity 2 hours after treatment.
resultsThe average pain reduction 2 hours posttreatment was not significantly different between the groups. Post hoc analyses suggest asimadoline was effective in mixed IBS (P = .003, unadjusted), but may be worse in diarrhea-predominant IBS (P = .065 unadjusted). The anxiety score was reduced modestly by asimadoline (P = .053). No significant adverse effects were noted.
conclusionsAn on-demand dosing schedule of asimadoline was not effective in reducing severity of abdominal pain in IBS. Further studies in visceral pain and IBS appear warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.