ArticleNeuroscience2007
Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain.
Article in Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 73 citations in OpenAlex.
- Molecular cues from distinct neuron classes drive differential myelination in the neocortex.Developmental cell · 2026Article
- Live-cell physiology in human brain tissue culture-the potential, the challenges, and the lessons learned.Frontiers in cellular neuroscience · 2026Review
- A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis.Cell reports. Medicine · 2024Article
- Oncolytic Effect of Zika Virus in Neuroendocrine Pancreatic Tumors: New Perspectives for Therapeutic Approaches.International journal of molecular sciences · 2023Article
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- An ImprovedFrontiers in neuroscience · 2019Article
- Oligodendrocyte-Neuron Interactions: Impact on Myelination and Brain Function.Neurochemical research · 2018Article
- Polysialylation at Early Stages of Oligodendrocyte Differentiation Promotes Myelin Repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Biological roles of glycans.Glycobiology · 2017Review
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- Extracellular cues influencing oligodendrocyte differentiation and (re)myelination.Experimental neurology · 2016Review
- Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon Regeneration.Frontiers in molecular neuroscience · 2016Review
- Validation of In utero Tractography of Human Fetal Commissural and Internal Capsule Fibers with Histological Structure Tensor Analysis.Frontiers in neuroanatomy · 2015Article
- White matter astrocytes in health and disease.Neuroscience · 2014Review
- Heterogeneity of oligodendrocyte progenitor cells in adult human brain.Annals of clinical and translational neurology · 2014Article
- Promoting return of function in multiple sclerosis: An integrated approach.Multiple sclerosis and related disorders · 2013Article
- Myelin recovery in multiple sclerosis: the challenge of remyelination.Brain sciences · 2013Article
- Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain.British journal of anaesthesia · 2013Article
- Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Geomagnetic disturbances may be environmental risk factor for multiple sclerosis: an ecological study of 111 locations in 24 countries.BMC neurology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The polysialic acid (PSA) modification of neural cell adhesion molecule, which reduces neural cell adhesion molecule (NCAM) - mediated cell adhesion, is involved in several developmental processes, such as cell migration, axonal growth, path finding, and synaptic plasticity. It has been suggested that PSA-NCAM expression may inhibit myelination. To clarify the relationship between myelination and the expression of PSA-NCAM we systematically investigated its expression in the human forebrain from embryonic stage to midgestation (19-24 gestation weeks, gw). Immunofluorescence on cryosections showed that PSA-NCAM is expressed at the earliest stage studied (5.5 gw) in the primordial plexiform layer of the telencephalon, which mainly consists of neuronal processes. At midgestation, cortical axonal tracts in the emerging white matter were PSA-NCAM+, but they were not yet myelinated, based on the lack of myelin basic protein (MBP) immunoreaction. To follow the progression of myelination we developed organotypic slice cultures that included the subventricular and intermediate zones of the fetal forebrain. In freshly prepared slices, similar to cryosections, axonal tracts were PSA-NCAM+ but did not express MBP. After 5 days in culture there was a dramatic increase in MBP expression around the axons of the intermediate zone, which suggested the onset of myelination. Simultaneously with MBP up-regulation PSA-NCAM expression in axons was completely lost, as demonstrated both with immunofluorescence and Western blot analysis. These results support the idea that in the human fetal forebrain axonal PSA-NCAM expression is inversely related to primary myelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.