ArticleBMC evolutionary biology2007
High variability and non-neutral evolution of the mammalian avpr1a gene.
Article in BMC evolutionary biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Sensogenomics of music and Alzheimer's disease: An interdisciplinary view from neuroscience, transcriptomics, and epigenomics.Frontiers in aging neuroscience · 2023Pooled it
- Single-library chromosome-scale diploid assemblies of vole genomes resolve a species-specific duplication implicated in pair bonding.bioRxiv : the preprint server for biology · 2026Article
- Sex-specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain.eLife · 2026Article
- Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review.Frontiers in genetics · 2023Article
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- Comparison of the pharmacological profiles of arginine vasopressin and oxytocin analogs at marmoset, macaque, and human vasopressin 1a receptor.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
- Hypothesizing Music Intervention Enhances Brain Functional Connectivity Involving Dopaminergic Recruitment: Common Neuro-correlates to Abusable Drugs.Molecular neurobiology · 2017Article
- Complete genome of a Puumala virus strain from Central Europe.Virus genes · 2015Article
- Species, sex and individual differences in the vasotocin/vasopressin system: relationship to neurochemical signaling in the social behavior neural network.Frontiers in neuroendocrinology · 2015Review
- Molecular variation in AVP and AVPR1a in New World monkeys (Primates, Platyrrhini): evolution and implications for social monogamy.PloS one · 2014Article
- Article
- avpr1a length polymorphism is not associated with either social or genetic monogamy in free-living prairie voles.Animal behaviour · 2011Article
- AVPR1A sequence variation in monogamous owl monkeys (Aotus azarai) and its implications for the evolution of platyrrhine social behavior.Journal of molecular evolution · 2010Article
- Global microsatellite content distinguishes humans, primates, animals, and plants.Molecular biology and evolution · 2009Article
- Increased expression and protein divergence in duplicate genes is associated with morphological diversification.PLoS genetics · 2009Article
- A complex selection signature at the human AVPR1B gene.BMC evolutionary biology · 2009Article
- Musical aptitude is associated with AVPR1A-haplotypes.PloS one · 2009Article
- Allele distribution and effect on reporter gene expression of vasopressin receptor gene (AVPR1a)-linked VNTR in primates.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Music genetics research: Association with musicality of a polymorphism in the AVPR1A gene.Genetics and molecular biologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe arginine-vasopressin 1a receptor has been identified as a key determinant for social behaviour in Microtus voles, humans and other mammals. Nevertheless, the genetic bases of complex phenotypic traits like differences in social and mating behaviour among species and individuals remain largely unknown. Contrary to previous studies focusing on differences in the promotor region of the gene, we investigate here the level of functional variation in the coding region (exon 1) of this locus.
resultsWe detected high sequence diversity between higher mammalian taxa as well as between species of the genus Microtus. This includes length variation and radical amino acid changes, as well as the presence of distinct protein variants within individuals. Additionally, negative selection prevails on most parts of the first exon of the arginine-vasopressin receptor 1a (avpr1a) gene but it contains regions with higher rates of change that harbour positively selected sites. Synonymous and non-synonymous substitution rates in the avpr1a gene are not exceptional compared to other genes, but they exceed those found in related hormone receptors with similar functions. DISCUSSION: These results stress the importance of considering variation in the coding sequence of avpr1a in regards to associations with life history traits (e.g. social behaviour, mating system, habitat requirements) of voles, other mammals and humans in particular.
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