ArticleJournal of bioenergetics and biomembranes2008
Enhanced alternative oxidase and antioxidant enzymes under Cd(2+) stress in Euglena.
Article in Journal of bioenergetics and biomembranes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 42 citations in OpenAlex.
- Mitochondrial electron transport chain is essential for acute inflammatory stress responses in mouse fibroblasts.Scientific reports · 2026Article
- Unraveling the stress response and biosorption mechanisms ofFrontiers in microbiology · 2025Article
- Heavy metal-induced stress in eukaryotic algae-mechanisms of heavy metal toxicity and tolerance with particular emphasis on oxidative stress in exposed cells and the role of antioxidant response.Environmental science and pollution research international · 2022Review
- Early gene expression response of barley root tip to toxic concentrations of cadmium.Plant molecular biology · 2022Article
- Alternative Pathway Is Involved in Hydrogen Peroxide-Enhanced Cadmium Tolerance in Hulless Barley Roots.Plants (Basel, Switzerland) · 2021Article
- Metabolic Responses of a Model Green MicroalgaFrontiers in bioengineering and biotechnology · 2021Article
- Impact of antimycin A and myxothiazol on cadmium-induced superoxide, hydrogen peroxide, and nitric oxide generation in barley root tip.Protoplasma · 2019Article
- Cadmium activates both diphenyleneiodonium- and rotenone-sensitive superoxide production in barley root tips.Planta · 2016Article
- Alternative oxidase: a mitochondrial respiratory pathway to maintain metabolic and signaling homeostasis during abiotic and biotic stress in plants.International journal of molecular sciences · 2013Review
- Metal-induced oxidative stress and plant mitochondria.International journal of molecular sciences · 2011Review
- Two-dimensional liquid chromatography technique coupled with mass spectrometry analysis to compare the proteomic response to cadmium stress in plants.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify some of the mechanisms involved in the high resistance to Cd(2+) in the protist Euglena gracilis, we studied the effect of Cd(2+) exposure on its energy and oxidative stress metabolism as well as on essential heavy metals homeostasis. In E. gracilis heterotrophic cells, as in other organisms, CdCl(2) (50 microM) induced diminution in cell growth, severe oxidative stress accompanied by increased antioxidant enzyme activity and strong perturbation of the heavy metal homeostasis. However, Cd(2+) exposure did not substantially modify the cellular respiratory rate or ATP intracellular level, although the activities of respiratory complexes III and IV were strongly decreased. In contrast, an enhanced capacity of the alternative oxidase (AOX) in both intact cells and isolated mitochondria was determined under Cd(2+) stress; in fact, AOX activity accounted for 69-91% of total respiration. Western blotting also revealed an increased AOX content in mitochondria from Cd(2+)-exposed cells. Moreover, AOX was more resistant to Cd(2+) inhibition than cytochrome c oxidase in mitochondria from control and Cd(2+)-exposed cells. Therefore, an enhanced AOX seems to be a relevant component of the resistance mechanism developed by E. gracilis against Cd(2+)-stress, in addition to the usual increased antioxidant enzyme activity, that enabled cells to maintain a relatively unaltered the energy status.
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