ReviewSeminars in immunopathology2007
Target antigens and nephritogenic antibodies in membranous nephropathy: of rats and men.
Review in Seminars in immunopathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Membranous Nephropathy: Antigenic Landscape and a Novel Pathogenetic Model.International journal of molecular sciences · 2026Review
- From immune dysregulation to renal injury: mechanistic insights and translational opportunities in immune-mediated nephropathies.Frontiers in cell and developmental biology · 2026Review
- Targeted Complement Treatments in Glomerulopathies: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Animal models of membranous nephropathy: more choices and higher similarity.Frontiers in immunology · 2024Review
- Determination of Anti-Phospholipase A2 and Anti-Thrombospondin Type 1 Domain-Containing Protein 7A in Latin Patients with Membranous Nephropathy.Diagnostics (Basel, Switzerland) · 2022Article
- Transforming Growth Factor Beta Receptor 3 (TGFBR3)-Associated Membranous Nephropathy.Kidney360 · 2021Article
- Role of Podocyte Injury in Glomerulosclerosis.Advances in experimental medicine and biology · 2019Review
- Anti-Phospholipase AImmunology, endocrine & metabolic agents in medicinal chemistry · 2016Article
- Identification of the immunodominant epitope region in phospholipase A2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy.Journal of the American Society of Nephrology : JASN · 2015Article
- Membranous nephropathy: not just a disease for adults.Pediatric nephrology (Berlin, Germany) · 2015Review
- The Effects of Helicobacter pylori Eradication on Proteinuria in Patients with Primary Glomerulonephritis.International journal of nephrology · 2014Article
- Anti-neutral endopeptidase, natriuretic peptides disarrangement, and proteinuria onset in membranous nephropathy.Molecular biology reports · 2013Review
- Upregulation of c-mip is closely related to podocyte dysfunction in membranous nephropathy.Kidney international · 2013Article
- Computational prediction and experimental assessment of an HLA-A*0201-restricted cytotoxic T lymphocyte epitope from neutral endopeptidase.Immunologic research · 2012Article
- An overview of molecular mechanism of nephrotic syndrome.International journal of nephrology · 2012Article
- Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside.Pediatric research · 2011Article
- Anti-phospholipase A2 receptor antibody in membranous nephropathy.Journal of the American Society of Nephrology : JASN · 2011Article
- Idiopathic membranous nephropathy associated with polycystic kidney disease.Pediatric nephrology (Berlin, Germany) · 2010Article
- Autoimmunity in membranous nephropathy targets aldose reductase and SOD2.Journal of the American Society of Nephrology : JASN · 2010Article
- Controversies in the treatment of idiopathic membranous nephropathy.Nature reviews. Nephrology · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membranous nephropathy, a disease characterized by an accumulation of immune deposits on the outer aspect of the glomerular basement membrane, is the most common cause of idiopathic nephrotic syndrome in white adults. In the rat model of Heymann nephritis, the target antigen of antibodies is megalin, a multiligand receptor expressed at the podocyte cell surface. This review summarizes key findings provided by this experimental model and by our discovery of neutral endopeptidase being the alloantigen involved in neonatal cases of membranous nephropathy. We discuss the role of alloimmunization as a new mechanism of renal disease and the approach that we use to identify new podocyte antigens. We also summarize current knowledge on the mechanism of proteinuria, with special emphasis on the role of complement. In conclusion, substantial progresses have been made in understanding molecular mechanisms of membranous nephropathy, which should lead to novel therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.