The enteroinsular axis may mediate the diabetogenic effects of TCF7L2 polymorphisms.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Serum Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide-1 (GLP-1) in association with the Risk of Gestational Diabetes: A Prospective Case-Control Study.Journal of diabetes research · 2020
   Article
2. COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways.PloS one · 2012
   Article
3. Defects in insulin secretion and action in the pathogenesis of type 2 diabetes mellitus.Current diabetes reports · 2010
   Review
4. The contribution of enteroinsular hormones to the pathogenesis of type 2 diabetes mellitus.Current diabetes reports · 2010
   Review
5. Is the diminished incretin effect in type 2 diabetes just an epi-phenomenon of impaired beta-cell function?Diabetes · 2010
   Review
6. The T-allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest.Diabetes · 2010
   Article
7. The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.Diabetologia · 2009
   Article
8. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.Human molecular genetics · 2009
   Article
9. TCF7L2 genetic defect and type 2 diabetes.Current diabetes reports · 2008
   Review

Corrections and comments

• Comment on
  Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.2007

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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