ArticleNeoplasia (New York, N.Y.)2007
Flat-panel detector-based volume computed tomography: a novel 3D imaging technique to monitor osteolytic bone lesions in a mouse tumor metastasis model.
Article in Neoplasia (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- 3D virtual histology of murine kidneys -high resolution visualization of pathological alterations by micro computed tomography.Scientific reports · 2018Article
- In vivo detection of small tumour lesions by multi-pinhole SPECT applying a (99m)Tc-labelled nanobody targeting the Epidermal Growth Factor Receptor.Scientific reports · 2016Article
- Micro-CT of rodents: state-of-the-art and future perspectives.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2014Review
- Non-invasive microCT imaging characterization and in vivo targeting of BB2 receptor expression of a PC-3 bone metastasis model.Molecular imaging and biology · 2012Article
- CEACAM1 creates a pro-angiogenic tumor microenvironment that supports tumor vessel maturation.Oncogene · 2011Article
- Article
- Osteopenia due to enhanced cathepsin K release by BK channel ablation in osteoclasts.PloS one · 2011Article
- Musculoskeletal response to whole-body vibration during fracture healing in intact and ovariectomized rats.Calcified tissue international · 2010Article
- Cancer metastasis as a therapeutic target.European journal of cancer (Oxford, England : 1990) · 2010Review
- The War on Cancer rages on.Neoplasia (New York, N.Y.) · 2009Article
- Neoplasia: the second decade.Neoplasia (New York, N.Y.) · 2008Article
- Morphologic changes of mammary carcinomas in mice over time as monitored by flat-panel detector volume computed tomography.Neoplasia (New York, N.Y.) · 2008Article
- Bevacizumab inhibits breast cancer-induced osteolysis, surrounding soft tissue metastasis, and angiogenesis in rats as visualized by VCT and MRI.Neoplasia (New York, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal metastasis is an important cause of mortality in patients with breast cancer. Hence, animal models, in combination with various imaging techniques, are in high demand for preclinical assessment of novel therapies. We evaluated the applicability of flat-panel volume computed tomography (fpVCT) to noninvasive detection of osteolytic bone metastases that develop in severe immunodeficient mice after intracardial injection of MDA-MB-231 breast cancer cells. A single fpVCT scan at 200-microm isotropic resolution was employed to detect osteolysis within the entire skeleton. Osteolytic lesions identified by fpVCT correlated with Faxitron X-ray analysis and were subsequently confirmed by histopathological examination. Isotropic three-dimensional image data sets obtained by fpVCT were the basis for the precise visualization of the extent of the lesion within the cortical bone and for the measurement of bone loss. Furthermore, fpVCT imaging allows continuous monitoring of growth kinetics for each metastatic site and visualization of lesions in more complex regions of the skeleton, such as the skull. Our findings suggest that fpVCT is a powerful tool that can be used to monitor the occurrence and progression of osteolytic lesions in vivo and can be further developed to monitor responses to antimetastatic therapies over the course of the disease.
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