ArticleNeoplasia (New York, N.Y.)2007
Functional analysis of the Aurora Kinase A Ile31 allelic variant in human prostate.
Article in Neoplasia (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01545518 (IVIG Treatment for Refractory Immune-Related Adult Epilepsy), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
IVIG Treatment for Refractory Immune-Related Adult Epilepsy
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- AURKA rs2273535 T>A Polymorphism Associated With Cancer Risk: A Systematic Review With Meta-Analysis.Frontiers in oncology · 2020Pooled it
- Review
- Gene expression profile of human colorectal cancer identified NKTR as a biomarker for liver metastasis.Aging · 2022Article
- AURKA gene polymorphisms and central nervous system tumor susceptibility in Chinese children.Discover oncology · 2021Article
- Identification of candidate biomarkers correlated with poor prognosis of breast cancer based on bioinformatics analysis.Bioengineered · 2021Article
- Combined effect of genetic polymorphisms of AURKA and environmental factors on oral cancer development in Taiwan.PloS one · 2017Article
- SEPT14 Is Associated with a Reduced Risk for Parkinson's Disease and Expressed in Human Brain.Journal of molecular neuroscience : MN · 2016Article
- Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients.Journal of ovarian research · 2016Article
- Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer.Oncotarget · 2015Article
- KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity.Journal of biomedical science · 2015Article
- Association of genetic and non-genetic risk factors with the development of prostate cancer in Malaysian men.Molecular biology reports · 2014Article
- Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function.Molecular carcinogenesis · 2013Article
- DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population.Journal of hematology & oncology · 2013Article
- Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of Aurora A expression and function.PloS one · 2012Article
- Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.International journal of cancer · 2011Article
- The War on Cancer rages on.Neoplasia (New York, N.Y.) · 2009Article
- Bladder cancer SNP panel predicts susceptibility and survival.Human genetics · 2009Article
- Neoplasia: the second decade.Neoplasia (New York, N.Y.) · 2008Article
- San Huang Decoction Targets Aurora Kinase A to Inhibit Tumor Angiogenesis in Breast Cancer.Integrative cancer therapiesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of the centrosome-associated serine/threonine kinase Aurora Kinase A (AURKA) has been demonstrated in both advanced prostate cancer and high-grade prostatic intraepithelial neoplasia lesions. The single-nucleotide polymorphism T91A (Phe31Ile) has been implicated in AURKA overexpression and has been suggested as a low-penetrance susceptibility allele in multiple human cancers, including prostate cancer. We studied the transcriptional consequences of the AURKA Ile31 allele in 28 commercial normal prostate tissue RNA samples (median age, 27 years). Significant overexpression of AURKA was demonstrated in homozygous and heterozygous AURKA Ile31 prostate RNA (2.07-fold and 1.93-fold, respectively; P < .05). Expression levels of 1509 genes differentiated between samples homozygous for Phe31 alleles and samples homozygous for Ile31 alleles (P = .05). Gene Ontology classification revealed overrepresentation of cell cycle arrest, ubiquitin cycle, antiapoptosis, and angiogenesis-related genes. When these hypothesis-generating results were subjected to more stringent statistical criteria, overexpression of a novel transcript of the natural killer tumor recognition sequence (NKTR) gene was revealed and validated in homozygous Ile31 samples (2.6-fold; P < .05). In summary, our data suggest an association between the AURKA Ile31 allele and an altered transcriptome in normal non-neoplastic prostates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.